Navigation Links
deCODE Genetics, in Collaboration with Academic Colleagues and Illumina, Discovers Two Rare Variants that Affect the Risk of Gout and Serum Uric Acid Levels
Date:10/9/2011

ating with serum uric acid level and gout. The variant decreases the risk of gout by 50%, and the level of uric acid by 0.05 mmol/L. Approximately 3% of the Icelandic population carry this variant and 1.5% of the European subjects.

For both loci the effect on risk of gout is significantly higher among men than women, but the effect on serum uric acid levels is the same in both sexes.

"This study underscores the importance of whole genome sequencing of well-phenotyped populations.  We are pleased that the clinical and genetic resource that deCODE has built enables us to make such discoveries," said Kari Stefansson, deCODE's CEO and senior author of the study.  

"We are committed to turning discoveries such as this, as well as our recent findings in ovarian cancer and sick sinus syndrome, and our future discoveries, into real benefit for patients," Dr. Stefansson continued.

Gout is a common inflammatory arthritis caused by urate crystal formation resulting from a high concentration of uric acid in the blood, which is in turn caused by an imbalance in the dietary intake of purines and in the synthesis an excretion of urate. The incidence of gout increases with age and is three times higher in men than in women.

About deCODE

Headquartered in Reykjavik, Iceland, deCODE genetics is a global leader in analyzing and understanding the human genome. Using its unique expertise and population resources, deCODE has discovered genetic risk factors for dozens of common diseases ranging from cardiovascular disease to cancer.

In order to most rapidly realize the value of genetics for human health, deCODE is currently partnering with life sciences companies to accelerate their target discovery, validation, and prioritization efforts, yielding improved patient stratification for clinical trials and essential companion diagnostics. In addition, through its CLIA- and CAP-certified laboratory, deCODE offers DNA-base
'/>"/>

SOURCE deCODE genetics
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. deCODE genetics to Webcast Presentation at Thomas Weisel Partners Healthcare Conference 2008
2. Researchers decode viral process that prepares cells for HIV infection
3. deCODE Receives Nasdaq Deficiency Notice Relating to Market Value
4. deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer
5. deCODE genetics Announces Webcast of Conference Call to Discuss Third Quarter 2008 Financial Results
6. deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter
7. deCODE genetics Announces Third Quarter 2008 Financial Results
8. deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
9. Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy
10. deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service
11. deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , Not for release, publication or distribution (in ... where to do so would constitute a violation of the ... or the "Company") (LSE: SHP, NASDAQ: SHPG ) ... held a meeting with representatives of AbbVie. This ... or approval of AbbVie. A further update will ...
(Date:7/11/2014)... 11, 2014 BCC Research ( http://www.bccresearch.com ... POLYMERASE CHAIN REACTION (PCR) TECHNOLOGY: GLOBAL MARKETS , the ... reached nearly $140 billion in 2013. This is estimated ... five-year compound annual growth rate (CAGR) of 28.6%. , ... interesting and exciting possibilities within the broader PCR field. ...
(Date:7/11/2014)... 2014 /CNW/ - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today ... acetate) for use as a once-daily adjunctive therapy for ... who are not satisfactorily controlled with conventional therapy.  APTIOM ... under 18 years of age. Epilepsy ... according to Epilepsy Canada, it affects 0.6% of the ...
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
Breaking Biology Technology:Shire plc - Statement re: Media Speculation 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3
... Laboratory (IL) today announced that their Strategic Alliance ... June 22, 2012, after more than twenty successful ... direct sales, service, support and marketing to end-user ... own Hemostasis product line, including the HemosIL® line ...
... Pharmaceuticals today announced that the United States Patent and ... entitled, "Antibodies specific to heterodimers of Bcl-2 family and ... method for extending Eutropics, BH3 profiling technology, which is ... technology assesses the ability of a key part of ...
... 2012  Sangamo BioSciences, Inc. (Nasdaq: SGMO ) announced ... an update on the progress of Sangamo,s ZFP Therapeutic® development ... the following conferences: , The 11th Annual JMP ... PT (6:00 pm ET), on Monday, May 14, 2012. ...
Cached Biology Technology:Instrumentation Laboratory Moves To Direct Distribution Of Hemostasis Product Line In North America 2Instrumentation Laboratory Moves To Direct Distribution Of Hemostasis Product Line In North America 3Eutropics Pharmaceuticals Receives U.S. Patent for Novel Diagnostic Method 2Sangamo BioSciences Announces Presentations At Upcoming Investor Conferences 2
(Date:7/11/2014)... from Salk Institute for Biological Studies, BGI, and ... safety and reliability of the existing targeted gene ... TALEN-HDAdV, which could significantly increased gene-correction efficiency in ... published online in Cell Stell Cell ... gene therapy. , The combination of stem cells ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/11/2014)... normal circumstances, astrocytes participate in normal physiological ... exhibit therapeutic and repairing effects on brain ... found that nerve cells differentiated from adipose-derived ... viability, which produces influences on subsequent studies ... Hospital, Hebei United University, China demonstrated that ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... of a gene that optimizes their brain's thinking circuitry, ... severe mental illness marked by impaired thinking, scientists at ... Mental Health (NIMH) have discovered. The seeming paradox ... of variation in the human gene for a brain ...
... of epicatechin, a compound found in cocoa, are so striking ... importance to public health, reports Marina Murphy in Chemistry & ... medicine at Harvard Medical School, told C&I that epicatechin is ... , Hollenberg has spent years studying the benefits of cocoa ...
... Researchers from Université Laval’s Faculty of Medicine have ... antiwrinkle products causes a pathological reaction in skin ... present their conclusions about the mode of action ... the British Journal of Dermatology. , DMAE (2-dimethylaminoethanol) ...
Cached Biology News:Common gene version optimizes thinking -- but with a possible downside 2Cocoa 'vitamin' health benefits could outshine penicillin 2Anti-wrinkle compound causes pathological reaction in skin cells 2
The 12-Tube Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 12 microcentrifuge tubes. ,Magnets: Neodymium rare earth permanent ma...
DONOR BOVINE SERUM AND PLASMA...
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: