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deCODE Discovers Genetic Risk Factor Linking Susceptibility to Four Major Vascular Diseases
Date:7/12/2010

REYKJAVIK, Iceland, July 12, 2010 /PRNewswire-FirstCall/ -- Points to Novel Pathway for Drug Discovery, Will be Incorporated Into Tests to Improve Screening and Early Detection of Abdominal Aortic Aneurysm, Heart Attack and PAD

Scientists at deCODE genetics and academic colleagues from the Netherlands and twelve other countries across Europe and North America today report the discovery of a common single-letter variation (SNP) in the sequence of the human genome conferring risk of a range of vascular diseases. The SNP confers risk of abdominal aortic aneurysm (AAA), early-onset heart attack, peripheral artery disease (PAD), and pulmonary embolism, independent of other known risk factors. It will be integrated into deCODE's DNA-based tests to improve the assessment of individual risk and the targeting of screening and prevention strategies. The SNP, rs7025486, is located in an intron of the DAB21P gene on chromosome 9q33. The gene encodes an inhibitor of cell growth and survival that is expressed in cardiovascular tissue.

"This is the sort of discovery that makes human genetics such an exciting field of endeavour. By incorporating this with other major genetic risk factors we include in our tests, such as those on 9p21, we are empowering physicians to identify greater numbers of those at high risk and who should therefore benefit from closer monitoring and prevention strategies. In the case of AAA, for example, this can be used along with traditional risk factors to identify those who should have ultrasound screening, leading to the detection of more aneurysms earlier, potentially saving lives," said Kari Stefansson, deCODE's executive
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SOURCE DeCODE Genetics Inc
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