deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men... (mately 20000 participants in thecompany'...)

deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women

Date:1/31/2008

mately 20,000 participants in the company's gene discovery programs. The SNPs, referred to as rs3796619 and rs1670533, are within the RNF212 gene, and are estimated to account for approximately 22% of paternal variability in recombination and 6.5% of maternal variability. Little is known about RNF212, though it is a mammalian homolog of a gene called ZHP-3 known to be crucial for the success of recombination in other organisms. The paper, entitled 'Sequence Variants in the RNF212 Gene Associate with Genomewide Recombination Rate,' is published today in the online edition of Science, at http://www.sciencemag.org/sciencexpress.

deCODE has made a number of breakthrough discoveries in the understanding of recombination, fertility and human evolution. In 2002, deCODE published the most detailed recombination map to date of the genome, demonstrating that there are hotspots and coldspots for recombination in all chromosomes, and that these are very different in women and men. This map provided a template for completing the final assembly of the sequence of the human genome. deCODE scientists then showed that recombination rate varies between families and between women; that recombination rate increases with the age of the mother; and that higher recombination rate correlates with fertility, indicating that evolution appears to place a premium on the generation of human diversity. In 2005, deCODE identified a genetic variant that correlates with higher recombination rate, the first genetic variant ever demonstrated to be under positive evolutionary selection in human populations in real time. References for these and all deCODE's major discoveries can be found at http://www.decode.com.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of drugs and diagnostics for common disea
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deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men...(mately 20000 participants in thecompany'...)