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deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
Date:4/27/2008

chromosome 5p12.

deCODE gratefully acknowledges the participation of the patients and researchers who took part in this study.

About Breast Cancer

Breast cancer is the most common cancer and the second leading cause of cancer deaths among women. Breast cancers are classified as ER+ or ER- according to whether tumors are found to contain estrogen receptors; in women of European descent approximately three-quarters are ER+, and in women of African descent approximately 50% are ER+. An estimated 178,000 cases are diagnosed in the US every year and over 40,000 deaths will result from breast cancer. Though a substantial portion of risk of this common disease is clearly familial, it has taken painstaking research to find genetic variants predisposing to its common forms. The strongly predisposing mutations in the BRCA1 and BRCA2 genes have a less than 0.5% frequency in the general population in the US and Europe. These mutations are estimated to account for only 1-3% of all breast cancer cases. There is evidence that a substantial portion of the uncharacterized risk for breast cancer is genetic, and this has encouraged the search for additional breast cancer predisposition genes.

About deCODE

deCODE is a biopharmaceutical company applying its discoveries in human genetics to the development of diagnostics and drugs for common diseases. deCODE is a global leader in gene discovery - our population approach and resources have enabled us to isolate key genes contributing to major public health challenges from cardiovascular disease to cancer, genes that are providing us with drug targets rooted in the basic biology of disease. Through its CLIA-certified laboratory, deCODE is offering a growing range of DNA-based tests for gauging risk and empowering prevention of common diseases, including deCODE T2(TM) for type 2 diabetes; deCODE AF(TM) for atrial fibrillation and stroke; deCODE MI(TM) for heart attack; and deCODE PrCa(TM) for prostate can
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