Navigation Links
deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
Date:4/27/2008

breast cancers, appear to confer risk exclusively of ER+ tumors. deCODE is applying these variants as the basis for a DNA-based reference laboratory risk-assessment test the company plans to launch in the coming months. Such a test will allow for the identification of women who may benefit from regular screening with standard as well as new, high-resolution technologies. The American Cancer Society now recommends that women who are at a 20-50% above- average risk of breast cancer should consider undergoing annual magnetic- resonance imaging (MRI) scans as well as mammograms.

"Within the past two years we have identified specific sequence variants that underlie much of the inherited risk of the common forms of breast cancer, the most frequently diagnosed cancer in women. And we have now reached a long awaited tipping point in this progress: the ability to identify, through a simple genetic test, a large proportion of women who are at a clinically- meaningful risk of the disease. The rationale for such testing is all the more compelling in ER+ cancers, since drugs such as tamoxifen have been shown to be successful in preventing as well as treating these cancers, and other drugs now in development may prove to be safe as long-term prophylactic therapy as well. deCODE's pioneering work in this field has also demonstrated that ER+ and ER- breast cancer appear to have distinct genetic bases, a phenomenon which may open the way to a better understanding of the nature, treatment and prevention of breast cancer in general. One of the most pressing next steps in this research is to analyze these results in large cohorts of women of non- European descent," said Kari Stefansson, CEO of deCODE.

deCODE made today's discovery through the analysis of genotypic data from a total of nearly 40,000 patients and control subjects from five countries. The deCODE team analyzed both genome-wide data on some 300,000 SNPs, supplemented by data on a much smaller number of SNPs on
'/>"/>

SOURCE deCODE genetics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information
2. deCODE genetics Announces Webcast of Conference Call to Discuss First Quarter 2008 Financial Results
3. U.S. Preventive Medicine and deCODE Genetics Sign Letter of Intent to Expand Personalized Medicine Platform
4. A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
5. deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference
6. deCODE genetics to Webcast Presentation at Lehman Brothers Eleventh Annual Global Healthcare Conference
7. deCODE Genetics Announces Full-year 2007 Financial Results
8. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
9. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
10. deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women
11. deCODE genetics to Webcast Presentation at JPMorgan Annual Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... Three Lawrence Livermore researchers have received ... R&D Award for their research in producing ... , Shared with collaborators from the National Renewable ... Las Vegas (UNLV), the award recognizes the team ... production and corrosion processes. , These models have ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... A new research platform uses a laser ... structures undergoing stress and heating, an approach ... for microelectronics and batteries., This new technique, ... how heating and the surface stress of ... have discussed the merits of surface-stress influence ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
Breaking Biology Technology:Livermore Team Awarded for Hydrogen Production Research 2Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2
... product to poultry, red meat and pork processing ... ... 19 Tasker Products Corp.,(OTC Bulletin Board: TKER), a distributor and ... has received authorization from the Food Safety and Inspection,Service ("FSIS") of ...
... Biotechnologies,announced today the results of an on-going Phase I/II ... ASCO meeting, 2008).,Continuing on with the planned dose-escalations of ... in a Phase I safety study (Molecular,Therapy, 2008), the ... i.v. two to three times a week for 4,weeks, ...
... Lack of Global Statistics Prompts Creation of First Global,Resource ... Alliance, a newly formed Non-Governmental,Organisation, today called on governments ... prevention, diagnosis and treatment for people living,with chronic viral ... that 500 million, approximately one in 12,people, are infected ...
Cached Biology Technology:Tasker Products Receives Authorization from USDA for its Tasker Clear for use in Meat and Pork Industries 2Tasker Products Receives Authorization from USDA for its Tasker Clear for use in Meat and Pork Industries 3ASCO 2008: Tumor-Targeted Rexin-G Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Metastatic Pancreatic Cancer 2World Hepatitis Alliance Calls on Governments to Take Urgent Action to Tackle Chronic Viral Hepatitis B & C Epidemic 2World Hepatitis Alliance Calls on Governments to Take Urgent Action to Tackle Chronic Viral Hepatitis B & C Epidemic 3
(Date:8/31/2014)... new study of satellite data from the last 19 years ... sea-level around the coast of Antarctica to rise by 2cm ... the University of Southampton detected the rapid rise in sea-level ... than a million square kilometres. , The melting ... ice shelves has contributed an excess of around 350 gigatonnes ...
(Date:8/31/2014)... CAMBRIDGE, MA -- Over the past several decades, malaria diagnosis ... a patient, a technician smears the blood across a glass ... a microscope for the Plasmodium parasite, which causes the disease. ... are in the blood an important measure of disease ... for human error. , A research team from the Singapore-MIT ...
(Date:8/29/2014)... UC Davis have made some surprising discoveries about ... simian immunodeficiency virus (SIV), the team found that ... are early responders to viral invasion and are ... cytokine called interleukin-1 beta (IL-1β). , Though ... breakdown of the gut epithelium that provides a ...
Breaking Biology News(10 mins):A new way to diagnose malaria 2A new way to diagnose malaria 3The early cost of HIV 2
... eastern Pacific populations of leatherback turtles, the 21st century ... change could exacerbate existing threats and nearly wipe out ... nests buried at hotter, drier beaches are the leading ... a new study in the journal Nature Climate ...
... 2012 Scientists at The Scripps Research Institute have discovered ... within cells. The scientists highlighted the medical potential of the ... to an experimental gene therapy against HIV infection. "We ... the troubles that have long been linked to traditional gene ...
... highly valued, highly cited research and reviews to the ... report that the new impact factors align with community ... the highest impact research and reviews in the biomedical ... by Thomas Reuters. Cell Press,s flagship journal ...
Cached Biology News:Rising heat at the beach threatens largest sea turtles, climate change models show 2Rising heat at the beach threatens largest sea turtles, climate change models show 3Scripps Research Institute Scientists Develop Alternative to Gene Therapy 2Scripps Research Institute Scientists Develop Alternative to Gene Therapy 3Scripps Research Institute Scientists Develop Alternative to Gene Therapy 4Cell Press journals continue to deliver high impact 2Cell Press journals continue to deliver high impact 3
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
Mouse monoclonal antibody raised against a partial recombinant JRKL. NCBI Entrez Gene ID = JRKL...
... Polymorphic DNA Technologies also offers a DNA ... of templates including plasmids, PCR products, BACs, ... customer-provided templates such as purified plasmids or ... liquid handling robotics optimized for automated reaction ...
... a premium quality recombinant form of Thermus ... suitable for a wide range of PCR ... reproducible performance, each preparation is extensively tested ... NovaTaq DNA Polymerase possesses an integral 5′→3′ ...
Biology Products: