Navigation Links
deCODE Discovers Fourth Major Set of Common Genetic Variants Linked to Risk of Estrogen Receptor-Positive Breast Cancer
Date:4/27/2008

breast cancers, appear to confer risk exclusively of ER+ tumors. deCODE is applying these variants as the basis for a DNA-based reference laboratory risk-assessment test the company plans to launch in the coming months. Such a test will allow for the identification of women who may benefit from regular screening with standard as well as new, high-resolution technologies. The American Cancer Society now recommends that women who are at a 20-50% above- average risk of breast cancer should consider undergoing annual magnetic- resonance imaging (MRI) scans as well as mammograms.

"Within the past two years we have identified specific sequence variants that underlie much of the inherited risk of the common forms of breast cancer, the most frequently diagnosed cancer in women. And we have now reached a long awaited tipping point in this progress: the ability to identify, through a simple genetic test, a large proportion of women who are at a clinically- meaningful risk of the disease. The rationale for such testing is all the more compelling in ER+ cancers, since drugs such as tamoxifen have been shown to be successful in preventing as well as treating these cancers, and other drugs now in development may prove to be safe as long-term prophylactic therapy as well. deCODE's pioneering work in this field has also demonstrated that ER+ and ER- breast cancer appear to have distinct genetic bases, a phenomenon which may open the way to a better understanding of the nature, treatment and prevention of breast cancer in general. One of the most pressing next steps in this research is to analyze these results in large cohorts of women of non- European descent," said Kari Stefansson, CEO of deCODE.

deCODE made today's discovery through the analysis of genotypic data from a total of nearly 40,000 patients and control subjects from five countries. The deCODE team analyzed both genome-wide data on some 300,000 SNPs, supplemented by data on a much smaller number of SNPs on
'/>"/>

SOURCE deCODE genetics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. deCODE Lauds Federal Legislation to Ban Discrimination on the Basis of Genetic Information
2. deCODE genetics Announces Webcast of Conference Call to Discuss First Quarter 2008 Financial Results
3. U.S. Preventive Medicine and deCODE Genetics Sign Letter of Intent to Expand Personalized Medicine Platform
4. A Smoking Gene: deCODE Shows How a Single Variant in the Sequence of the Genome Confers Nicotine Dependence and Risk of Lung Cancer and Other Disease
5. deCODE genetics to Webcast Presentation at 15th Annual Future Leaders in the Biotech Industry Conference
6. deCODE genetics to Webcast Presentation at Lehman Brothers Eleventh Annual Global Healthcare Conference
7. deCODE Genetics Announces Full-year 2007 Financial Results
8. deCODE genetics Announces Webcast of Conference Call to Discuss Full-year 2007 Financial Results
9. deCODE genetics to Webcast Presentation at BIO CEO and Investor Conference
10. deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women
11. deCODE genetics to Webcast Presentation at JPMorgan Annual Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... August 22, 2014 Nerium International, ... is in the spotlight again. Nerium will showcase ... its NeriumFirmTM Body Contouring Cream to Hollywood’s elite ... Creations during the 66th Primetime Emmy® Awards. , ... extract, third-party clinical trials show that NeriumAD night ...
(Date:8/21/2014)... 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... in class collagenase-based products marketed as XIAFLEX ® ... U.S. and XIAPEX ® in the EU, ... randomized, double-blind Phase 2a study of CCH for ... panniculopathy. The results showed that all three doses ...
(Date:8/21/2014)... DESY scientists has observed tiny quantum vortices in cold ... journal Science that the exotic vortices arrange ... is the first time that the quantum vortices, which ... is known as superfluid helium, have been detected in ... Andrey Vilesov of the University of Southern California, one ...
(Date:8/21/2014)... His Majesty Willem-Alexander, King of the Netherlands ... His Majesty Willem-Alexander, King of the Netherlands, has announced ... POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol plant in ... will take part in the Grand Opening Ceremony to ... p.m. and tour the plant. POET-DSM is a joint ...
Breaking Biology Technology:Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Scientists observe quantum vortices in cold helium droplets 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... Treatment Approved by the Fda For Hypotrichosis of,Eyelashes ... and Drug Administration (FDA) has approved LATISSE(TM),(bimatoprost ophthalmic ... the eyelashes. Eyelash hypotrichosis is another name for,having ... first and only,FDA-approved, science-based treatment to enhance eyelash ...
... WALTHAM, Mass., Dec. 26 Interleukin Genetics, Inc. (NYSE ... 2008 the Company received notice from the NYSE Alternext ... is not in compliance with certain conditions of the ... Company Guide. Specifically, the Exchange noted the Company,s failure ...
... Minimize Viral Transmission, Including Norovirus , A ... public health by minimizing the transmission of multiple ... providers. The researchers from the University of ... Raleigh report their findings in the August 2008 ...
Cached Biology Technology:MultiVu Video Feed: U.S Food and Drug Administration (Fda) Approves Latisse(TM) -- 2MultiVu Video Feed: U.S Food and Drug Administration (Fda) Approves Latisse(TM) -- 3Interleukin Genetics Receives Notification of Failure to Meet Continued Listing Standard Section 1003(a)(iii) 2Interleukin Genetics Receives Notification of Failure to Meet Continued Listing Standard Section 1003(a)(iii) 3Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4
(Date:8/21/2014)... American singles found that during sex with a ... On average, men experience orgasm 85.1 percent of ... difference. For women, however, orgasm occurrence is less ... of the time during sex with a familiar ... sexual orientation, with lesbian women experiencing orgasm more ...
(Date:8/21/2014)... unknown process for harvesting energy and producing oxygen from ... University scientist has discovered. The discovery lays the foundation ... energy from the Sun, and understanding dense blooms like ... worldwide. A paper describing the discovery will be published ... journal Science on 21 August 2014. , ...
(Date:8/21/2014)... linked to dandruff, eczema and other itchy, flaky maladies ... global reachesincluding Hawaiian coral reefs and the extreme environments ... review in the scientific journal PLOS Pathogens ... of the genus Malassezia in light of ... around the world. , University of Hawai,i at Mānoa ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... of Biological Sciences (AIBS) and the National Evolutionary ... and workshop for educators at the National Association ... The special symposium, which has become a ... classroom teachers with an opportunity to hear directly ...
... Research and Forestry Applications (CREAF), in the celebration of ... of international experts to discuss the environmental future of ... The work of both days is summarized in the ... Sustainability, which you will find bellow. Targeted to governments ...
... in age-related macular degeneration, the most common cause of ... today in the Lancet , adds to the ... (AMD), which the researchers believe should ultimately lead to ... people aged 80 years or older are affected by ...
Cached Biology News:Illuminating biology: An evolutionary perspective 2Illuminating biology: An evolutionary perspective 3Illuminating biology: An evolutionary perspective 4Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 2Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 3Barcelona Declaration 2008: Challenges and Pathways to Earth Sustainability 4Genetic finding implicates innate immune system in major cause of blindness 2
Large-capacity refrigerated incubator chamber holds up to 4 independently-operated shakers. Programmable heat, refrigeration, humidifcation are standard. Photosynthetic operation, optional....
Denhardt's powder mixture (for 50X stock solution)...
... for monitoring acetylcholinesterase (AChE) activity. This is ... 5 min), non-radioactive and easy to use ... natural substrate, acetylcholine. A series of coupled ... AChE into a change in luminescence. Inhibitors ...
Rabbit polyclonal to Vitronectin ( Abpromise for all tested applications). Antigen: Full length Vitronectin protein (Mouse). Entrez Gene ID: 7448 Swiss Protein ID: P04004...
Biology Products: