"Within the past two years we have identified specific sequence variants that underlie much of the inherited risk of the common forms of breast cancer, the most frequently diagnosed cancer in women. And we have now reached a long awaited tipping point in this progress: the ability to identify, through a simple genetic test, a large proportion of women who are at a clinically- meaningful risk of the disease. The rationale for such testing is all the more compelling in ER+ cancers, since drugs such as tamoxifen have been shown to be successful in preventing as well as treating these cancers, and other drugs now in development may prove to be safe as long-term prophylactic therapy as well. deCODE's pioneering work in this field has also demonstrated that ER+ and ER- breast cancer appear to have distinct genetic bases, a phenomenon which may open the way to a better understanding of the nature, treatment and prevention of breast cancer in general. One of the most pressing next steps in this research is to analyze these results in large cohorts of women of non- European descent," said Kari Stefansson, CEO of deCODE.
deCODE made today's discovery through the analysis of genotypic data
from a total of nearly 40,000 patients and control subjects from five
countries. The deCODE team analyzed both genome-wide data on some 300,000
SNPs, supplemented by data on a much smaller number of SNPs on
|SOURCE deCODE genetics|
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