Navigation Links
deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
Date:2/2/2009

REYKJAVIK, Iceland, February 2 /PRNewswire-FirstCall/ --

Scientists from deCODE genetics (Nasdaq: DCGN) today report the discovery of the first variation in the sequence of the human genome ever shown to confer increased risk of essential tremor. The single-letter variant (or SNP) was discovered by analyzing the genomes of a total of more than 16,000 patients and healthy subjects from Iceland, Austria, Germany and the United States. It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other. This makes the finding even more significant, for although essential tremor is a relatively common neurological condition, to date little has been known about the biology behind it. Variations in LINGO1 may contribute to neuronal degeneration and to inhibit normal processes of neuronal repair that may be involved in essential tremor, and the protein itself may provide a potentially effective target for the development of drugs to treat the condition. The paper, "Variant in the sequence of the LINGO1 gene confers risk of essential tremor," is published today in the online edition of Nature Genetics, at http://www.nature.com/ng.

"This discovery is an encouraging direct hit. It offers a clear example of how genetics can both increase our understanding of what a disease is and directly point the way to the development of new therapies. This SNP is in a gene involved in many of the processes that one would expect to be perturbed in patients with essential tremor. Because LINGO1 has be shown to have a negative impact on neuronal development and survival, inhibiting it with a small molecule drug may provide an effective approach for developing a treatment for the severe forms
'/>"/>

SOURCE DeCODE Genetics Inc
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. deCODE Sells Auction Rate Securities
2. Introducing deCODEme Cardio(TM) and deCODEme Cancer(TM)
3. deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
4. deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service
5. Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy
6. deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
7. deCODE genetics Announces Third Quarter 2008 Financial Results
8. deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter
9. deCODE genetics Announces Webcast of Conference Call to Discuss Third Quarter 2008 Financial Results
10. deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer
11. deCODE Receives Nasdaq Deficiency Notice Relating to Market Value

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2009)..., , NEW YORK, Dec. 1 ...arch report is available in its catalogue: ,, ...: Market dynamics and the changing healthcare and ...nker.com/p0165658/Emerging-Clinical-Trial-Location...g-healthcare-and-regulatory-environment.html ,...
(Date:12/1/2009)..., , SHANGHAI, Dec. 1 /PRNewswire-Asia...ary of ShangPharma, a leading China-based Contract...s a winner of the 2009 Deloitte,Technology Fast 50...wing high,tech companies in China. The award is a ...revenue growth from 2006 to 2008. , The r...
(Date:12/1/2009)... Enterprise level storage... care providers without breaking the bank. , ...csDrive, LLC. ( www.pacsdrive.com ), a medical i...a new DICOM compatible cloud storage service. The ...ealth care providers to securely archive medical i...
(Date:12/1/2009)..., , SAN DIEGO, Dec. 1 /PRNewswire... Board: AEMD) announced today that it will present...3, 2009 at 2:00 p.m. (PST) at the Luxe Hotel in Lo...es A. Joyce, will present a corporate overview and...progress for its lead product, the Hemopurifier...
Breaking Biology Technology:Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 2Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 3Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 4Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 5Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 6Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 7Reportlinker Adds Emerging Clinical Trial Locations - Eastern Europe: Market Dynamics and the Changing Healthcare and Regulatory Environment 8Shanghai ChemPartner Ranks 3rd among 2009 Deloitte Technology Fast 50 China Winning Companies 2Shanghai ChemPartner Ranks 3rd among 2009 Deloitte Technology Fast 50 China Winning Companies 3PacsDrive Announces Low Cost Medical Imaging Storage Service, Seeks to Alter Status Quo in Health Care IT 2Aethlon Medical to Present at LD MICRO Conference on December 3, 2009 2
...today,received information from Danske Bank, that ...ivsforsikring and Danske Fund FCP - through,acquis...hares of a nominal,value of each DKK 1 correspondi...voting rights in Exiqon A/S., About Exiqon, Exiq...scientific,expertise in gene expression with our p...
...ications bear more than a passing resemblance to d...erally to capture all the colors of the spectrum, ...t from across the spectrum moves through optical c...rcuits contain dimensions measured in nanometers. ...andidate in electrical engineering at Lehigh Unive...
...WYE ) has,announced that Bernard Poussot, 56, Wyet...umed the additional position of Chairman of the Bo...t to a previously announced election by the,Compan...a succession plan,that began in April 2006 when Mr...man. In January 2007, he was named President and C...
Other Biology Technology:Using a grating with a grade, engineers trap a rainbow 2Using a grating with a grade, engineers trap a rainbow 3
(Date:12/1/2009)... United States, the other from Canada, put the sat...ck, on remote Ellesmere Island, only 600 miles fro...what these "North Pole wolves" do in the long, dar...he world., "We first encountered 9-year-old Brut... Geological Survey (USGS) wolf researcher who has ...
(Date:12/1/2009)...wire/ -- iQor, a global provider of business proce... 2009 InfoWorld 100 Awards Top 100 IT project of... This was the first submission for iQor. ,, "We...us list of companies," said Vikas Kapoor, presiden...ng the way we do business, allowing us to work fas...
(Date:12/1/2009)...ideo of individual breast tissue cells reveals a n...otein that cycles between two major compartments i...mplete view of the internal signals that cause bre...ancer and are targets of drug development. , Th... factors, travels back and forth between the nucle...
Breaking Biology News(10 mins):North Pole wolf emails locations to researchers 2North Pole wolf emails locations to researchers 3iQor Named to InfoWorld 100 List of Top IT Projects of 2009 2ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus 2ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus 3ERK's got rhythm: Protein that controls cell growth found to cycle in and out of cell nucleus 4The Jones Center for Diabetes 26amp 3B Endocrine Wellness Selects Retasure to Enhance Diabetes Care 54138 1The Jones Center for Diabetes 26amp 3B Endocrine Wellness Selects Retasure to Enhance Diabetes Care 54138 2UT Southwestern physicians bust myths about insulin 54134 1UT Southwestern physicians bust myths about insulin 54134 2Cumberland Pharmaceuticals Announces Pricing of Its Initial Public Offering of Common Stock 13480 1Cumberland Pharmaceuticals Announces Pricing of Its Initial Public Offering of Common Stock 13480 2
...t seems size does matters after all. But for flyin...ty of Chicago researchers. , In the May 15, 2005,...entists described the effects of size and behavior...als were better gliders. , "Despite their lack of ...rial locomotors," said lead scientist and author J...
...ohns Hopkins infectious disease specialists who ha...combat HIV and AIDS worldwide are warning that lim...al therapies currently being distributed in Africa... can least afford to pay for them. , In an article...h online June 28, infectious disease specialist Jo...
...n early type of antibiotic-resistant bacteria that...0s has re-emerged as one of the community-acquired...in The Lancet tomorrow (Saturday 2 April 2005). , ...at caused a pandemic 40-50 years ago could mean th...be more widespread than previously expected, warns...
Other Biology News:Researchers reveal secrets of flying snakes 2Researchers reveal secrets of flying snakes 3Hopkins AIDS experts issue warning about global efforts to provide drug therapies 2Hopkins AIDS experts issue warning about global efforts to provide drug therapies 3Hopkins AIDS experts issue warning about global efforts to provide drug therapies 4Community MRSA is re-emergence of 1950s pandemic, study suggests 2
Acridine orange, hemizinc salt from Research Organics, Inc.
Auto/Zyme Reagent Set from Biomeda Corporation
DAPI from Research Organics, Inc.
Agarose, high EEO, Molecular Biology Grade from Research Organics, Inc.
Biology Products: