Navigation Links
deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
Date:2/2/2009

REYKJAVIK, Iceland, February 2 /PRNewswire-FirstCall/ --

Scientists from deCODE genetics (Nasdaq: DCGN) today report the discovery of the first variation in the sequence of the human genome ever shown to confer increased risk of essential tremor. The single-letter variant (or SNP) was discovered by analyzing the genomes of a total of more than 16,000 patients and healthy subjects from Iceland, Austria, Germany and the United States. It is located on the long arm of chromosome 15 in the LINGO1 gene, which encodes a protein that has been shown to affect how neurons are formed and signal each other. This makes the finding even more significant, for although essential tremor is a relatively common neurological condition, to date little has been known about the biology behind it. Variations in LINGO1 may contribute to neuronal degeneration and to inhibit normal processes of neuronal repair that may be involved in essential tremor, and the protein itself may provide a potentially effective target for the development of drugs to treat the condition. The paper, "Variant in the sequence of the LINGO1 gene confers risk of essential tremor," is published today in the online edition of Nature Genetics, at http://www.nature.com/ng.

"This discovery is an encouraging direct hit. It offers a clear example of how genetics can both increase our understanding of what a disease is and directly point the way to the development of new therapies. This SNP is in a gene involved in many of the processes that one would expect to be perturbed in patients with essential tremor. Because LINGO1 has be shown to have a negative impact on neuronal development and survival, inhibiting it with a small molecule drug may provide an effective approach for developing a treatment for the severe forms
'/>"/>

SOURCE DeCODE Genetics Inc
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. deCODE Sells Auction Rate Securities
2. Introducing deCODEme Cardio(TM) and deCODEme Cancer(TM)
3. deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
4. deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service
5. Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy
6. deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
7. deCODE genetics Announces Third Quarter 2008 Financial Results
8. deCODE Requests Hearing With Nasdaq Following Receipt of Staff Determination Letter
9. deCODE genetics Announces Webcast of Conference Call to Discuss Third Quarter 2008 Financial Results
10. deCODE Discovery Sheds Light on Risk of the Most Common Form of Skin Cancer
11. deCODE Receives Nasdaq Deficiency Notice Relating to Market Value
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 2014 Deep Research Report ... professional and in-depth research report on the ... Seaweed Fertilizer information, including Seaweed Fertilizer definition, ... well as industry overview. This research covers ... as well as global industry analysis covering ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
(Date:8/21/2014)... 2014 Mathematic studies at the Program for ... funded by the Jeffrey Epstein VI Foundation , have ... visually identified for elimination. These aggressive cells are the driver ... a topological map of what to look for when examining ... while tumor cells can be extracted from biopsy, it,s very ...
(Date:8/21/2014)... VIEW, Calif. , Aug. 21, 2014 /PRNewswire/ ... properties and behaviors based on external stimuli such ... poised to have a disruptive effect in multiple ... revolutionize the business landscape by printing objects ranging ... aerospace and automotive sectors. Logo - ...
Breaking Biology Technology:Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 2Internationals Seaweed Fertilizer Industry 2014 Development Trend Analysis in New Research Study at DeepResearchReports.com 3Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 2Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 3Frost & Sullivan: 4-D Printing to Usher in Age of Low-Labor, Fast-Paced Product Manufacturing 4
... — One computer just isn't enough. Researchers at the ... to big groups of tightly networked computers that share ... professors Wesley Smith and David Schwartz are working with ... their data-crunching tasks manageable. The system used is Condor, ...
... noticed but the IT industry is gripped in a mania for ... the new black, but since it's technology, I'll have to settle ... giving outsourcing some serious competition as the option of first resort ... ,Though it might not fly in the states of Kansas or ...
... the historical significance of this past Sunday? , ,Yes, it ... of V-E Day ("Victory in Europe"), but it was also ... is one of the world's greatest economists. These days, while ... in his seminal work "The Road to Serfdom," he was ...
Cached Biology Technology:Centralization mania takes over 2Centralization mania takes over 3Centralization mania takes over 4Midwest cities in fight over municipal broadband access 2Midwest cities in fight over municipal broadband access 3Midwest cities in fight over municipal broadband access 4
(Date:8/22/2014)... Diabetes affects nearly 10 percent of the U.S. ... finger pricking to test blood glucose levels. Fortunately, ... development of a protein that could lead to ... patients. In the American Chemical Society,s (ACS,) newest ... her "designer protein" that could eventually allow diabetics ...
(Date:8/22/2014)... of captive black rhino reproduction in Europe highlights ... breeding programmes. , Researchers from Chester Zoo, The ... carried out a six-year study which encompassed 90% ... Katie Edwards led the research as part of ... says: "Although some black rhinoceros breed well in ...
(Date:8/21/2014)... An international team of scientists including researchers from the University ... commonly known as canolain the journal Science . Their ... which is used widely in farming and industry. , ... Europe, but the winter crop is increasingly cultivated in Georgia. ... low levels of saturated fat and rich supply of omega-3 ...
Breaking Biology News(10 mins):Hormone analysis helps identify horny rhinos 2Canola genome sequence reveals evolutionary 'love triangle' 2
... - Elsevier, the world-leading publisher of scientific, technical and ... of today,s launch ceremonies for The International Year of ... Nations (UN) proclaimed 2011 as the International Year of ... and its contributions to mankind, under the theme "Chemistry ...
... early years of the AIDS epidemic, being infected with the virus ... with the development of antiretroviral therapy, many with HIV are now ... about half of all HIV-positive individuals will be older than 50. ... faster than adults in their 20s or 30s. And those in ...
... the filaree, or common stork,s bill, has been remarkably successful. ... now endemic in south-western states such as California, and the ... root of their success. Having launched as far as possible ... ground by repeatedly curling and unwinding a strap-like structure, known ...
Cached Biology News:Research suggests HIV causes rapid aging in key infection-fighting cells 2How spring-loaded filaree seeds self launch 2
MagSi uniform silica particles coated with a carboxyl group containing polymer, covalently attached to the bead surface....
MAb to Vasopressin Preservative: NaN3...
Mouse monoclonal [1C6/2] to Rad17 ( Abpromise for all tested applications). entrezGeneID: 5884 SwissProtID: Q9UPF5...
... glycoprotein. distributed in colon and rectum, ... lung and salivary gland tissues. ... and MUC2. Epitope: Tandem repeats ... MUC3 tandem repeat peptide Positive ...
Biology Products: