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Cellular Dynamics Announces Commercial Launch of iCell® Neurons for Neuroscience Drug Discovery
Date:12/13/2011

Pharmaceuticals, said, "CDI's human iPSC-derived neurons, iCell Neurons, offer unprecedented opportunities for drug discovery and development. The cells not only functionally express key ion channels and receptors but also form electrophysiologically active networks. These attributes of iCell Neurons help substantiate the possibility that these cells provide an exciting new human model of neuronal physiology that augments traditional ones, such as rat primary neurons and human neuronal cell lines."

iCell Neurons present a human platform that enables the modeling of healthy neuronal cells to improve the predictability of drug candidate efficacy and toxicity screens early in the pharmaceutical pipeline process. "The human brain represents a complex organ that has consistently proven difficult to model in vitro, and this is partially reflected in the lack of effective therapeutics to treat neurological diseases and disorders," said Chris Parker, Chief Commercial Officer. "Degenerative diseases, such as Alzheimer's, Parkinson's, and ALS, and genetic dispositions, such as Huntington's and muscular dystrophy, can also be modeled to better understand these disease states for drug discovery and eventual therapies."

Because iCell Neurons are human cells, they better recapitulate human biology. These cells are better predictors of drug candidate responses than current cell models, including immortalized cell lines and primary neurons isolated from rodent tissues, which present significant limitations in biological relevance, reproducibility, and scalability. 

Robert Palay, Chief Executive Officer of CDI, said, "iCell Neurons are the third iPSC-derived product CDI has now commercially launched. We launched the first product ever developed from iPS cells,

SOURCE Cellular Dynamics International, Inc.
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