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2.3.3 The Importance of Biomarkers for Regulatory Authorities
2.4 Applications of Biomarkers within the Global Healthcare System
2.4.1 Overview
2.4.2 Predictive Biomarkers for Assessing Drug Efficacy
2.4.3 Predictive Biomarkers for Assessing Drug Safety
2.4.4 Biomarkers for Clinical Prognosis
2.5 Imaging Biomarkers
2.5.1 A Brief History of Imaging Biomarkers
2.5.2 Importance of Imaging Biomarkers in Clinical Trials
2.5.3 Challenges with Using Imaging Biomarkers in Clinical Trials
2.5.4 Example of an Imaging Biomarker: Case of Parkinson's Disease
2.6 Genomic Biomarkers
2.6.1 Introduction
2.6.2 Genomic Biomarkers in Oncology
2.7 Companion Diagnostics
2.8 Personalised Medicine
2.9 The Impact of Biomarkers within the Pharmaceutical Industry
2.9.1 Introduction
2.9.2 Pfizer
2.9.3 Johnson & Johnson
2.9.4 GlaxoSmithKline
2.9.5 Sanofi
2.9.6 Novartis
2.9.7 AstraZeneca
2.9.8 Roche
2.9.9 Abbott Laboratories
2.9.10 Eli Lilly
2.9.11 Bristol-Myers Squibb
3. Technological Platforms for Biomarker Discovery and Leading Manufacturers, 2011
3.1 Introduction
3.2 Biomarker Discovery Technologies
3.2.1 Genomics Approaches to Biomarker Discovery
3.2.2 Proteomics Approaches to Biomarker Discovery
3.2.3 Metabolomics
3.2.4 Pharmacogenomics
3.2.5 Integrative Approaches
3.3 Leading Manufacturers of Biomarker Technologies
3.3.1 Affymetrix
3.3.1.1 Affymetrix GeneChip miRNA 2.0 Array
3.3.2 Agilent
3.3.2.1 Agilent's HPLC-Chip/6210 TOF MS
3.3.3 Stemina Biomarker Discovery
3.3.3.1 Stemina's DevTOX Assay
3.3.4 Crown Bioscience
3.4 The Future of Biomarker Discoveries
3.4.1 Microarray Platforms Have Been Overshadowed by Next-Generation Sequencing Technologies
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