Navigation Links
arGEN-X advances ARGX-113 into preclinical development for autoimmune disorders
Date:4/24/2013

takes the progression of our pipeline to an exciting new level. In its broadest sense, we can envisage such a product potentially supplanting intravenous immunoglobulin (IVIG) in the treatment of autoimmunity. As well as the specific product potential of ARGX-113, we intend to outlicense our ABDEG technology to partners seeking to enhance therapeutic antibody potency in autoimmune disease. Furthermore, we see immediate applicability of ABDEGs in improving the efficacy of chronic disease treatment with biologics, including in the orphan drug space."

About ABDEG

ABDEG technology exploits the known binding interaction of antibody Fc regions with the    neonatal Fc receptor (FcRn), which is expressed in endothelial, hematopoietic and epithelial cells, and is central to the process of antibody clearance from the circulation. Based on specific mutations contained within the Fc domain, ABDEGs have several clear therapeutic applications with exciting development potential. The first, exemplified by ARGX-113, uses mutation-bearing Fc fragments as products for the treatment of autoimmune disorders. The second introduces the ABDEG mutations into therapeutic antibody product Fc regions, creating a dual therapeutic effect mediated by the binding of both variable and constant regions. The third promotes the active clearance of anti-therapy antibodies provoked in patients undergoing prolonged treatment with biologics, such as enzyme replacement or antibody-based therapies. For further information about ABDEGs, see Patel D.A. 2011. Neonatal Fc Receptor blockade by Fc engineering ameliorates arthritis in a murine model. The Journal of Immunology.187:1015-1022.

About arGEN-X

arGEN-X is a clinical stage human therapeutic antibody company that is rapidly developing a product pipeline using its unique suite of antibody technologies. arGEN-X is creating first and best in class antibody therapeutics with highly differentiated target prod
'/>"/>

SOURCE arGEN-X
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Novartis Highlights Advances for Patients With Breast Cancer and Hematological Diseases With Over 160 SABCS and ASH Abstracts
2. Nabsys to Present DNA Sequence Data from Solid-State Nanodetectors at the Annual Advances in Genome Biology and Technology (AGBT) Meeting and the EMBL Omics and Personalized Health Conference
3. UWM discovery advances graphene-based electronics
4. Next-generation nanoelectronics: A decade of progress, coming advances
5. New metamaterial practical for optical advances
6. Biodetection 2012 Conference Brings Together Leading Organizations from Around the World to Address Challenges & Technology Advances in Detection and Identification of Biological Threats in Washington, DC from June 28-29, 2012
7. New Annual US$3 Million Fundamental Physics Prize Recognizes Transformative Advances in the Field
8. VisionGate Reports Advances In Its Cell-CT(TM) Automated 3D Cell Analysis Platform At ASC 2012 Scientific Meeting
9. Collegiate Inventors Honored for Innovative Science and Technology Advances
10. Computer memory could increase fivefold from advances in self-assembling polymers
11. H3 Biomedicine Expands Cambridge Facilities, Doubles Employee Base as Scientific Program Advances
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... Palo Alto, Calif. (PRWEB) November 20, 2014 ... (CHI), a nonprofit, public policy research organization representing ... and pharmaceutical firms, and PwC US ... other states in life sciences industry growth. The ... and 2013. The 2015 California Biomedical Industry ...
(Date:11/21/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on the ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/21/2014)... (TSXV: BRM) ("Biorem" or "the Company") today announced results for the ... complete 2014 third quarter financial statements and MD&A have been filed ... September 30, , Nine-months ended September 30, ( ... , 2013 , 2014 , 2013 ... 6,715 , 14,476 Gross profit , 521 ...
(Date:11/18/2014)... 2014 Athena Signature Series: Turning Cancer ‘Off’ ... Emerson, a professor in the Regulatory Biology Laboratory at the ... discovery points to an “off switch” for drug resistance in ... her local research is making a global impact in the ... then join host Cheryl K. Goodman, CEO of Social Global ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... 18, 2011 Palatin Technologies, Inc. (NYSE Amex: ... February 24, 2011 at 11:00 a.m. Eastern Time to discuss ... for its programs under development.   Schedule ... Q2 Fiscal Year 2011 Conference Call-Live Domestic Dial-In ...
... to sharpen images of celestial bodies can now help scientists ... of a mouse. Eric Betzig, a group leader at the ... his team,s latest work using adaptive optics for biology at ... of Science in Washington, D.C. during a press conference on ...
... (Nasdaq: CDXS ) today announced that Byron Dorgan, ... the company,s Board of Directors. Senator Dorgan retired from the ... U.S. Congress.   (Photo:   http://photos.prnewswire.com/prnh/20110217/SF50619 ) ... our Board," said Alan Shaw, Ph.D., President and Chief Executive ...
Cached Biology Technology:Improving microscopy by following the astronomers' guide star 2Improving microscopy by following the astronomers' guide star 3Improving microscopy by following the astronomers' guide star 4Former Senator Byron Dorgan Elected to Codexis Board 2
(Date:11/4/2014)... 2014 – University of Utah engineers developed the first ... fuel produce electricity without needing to ignite the fuel. ... portable electronics, off-grid power and sensors. , A study ... American Chemical Society journal ACS Catalysis . , ... reaction between a fuel and an oxygen-rich source such ...
(Date:11/4/2014)... --   3D scanner developer ... Fuel3D , a developer of 3D scanning solutions, today ... million (£4 million). This funding builds on the company,s initial ... paves the way for the commercial launch of the company,s ... was led by Chimera Partners and will be used to ...
(Date:11/3/2014)... , Nov. 3, 2014  NeuroSigma ® , ... life sciences company focused on commercialization of its ... for the treatment of neurological and neuropsychiatric disorders, ... Property has issued a Notice of Allowance for ... is co-owned by NeuroSigma and the Regents of ...
Breaking Biology News(10 mins):Jet-fueled electricity at room temperature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 2NeuroSigma Receives Notice of Allowance from the Mexican Institute of Industrial Property Covering Subcutaneous Trigeminal Nerve Stimulation (sTNS) 3
... exhaust particles from traffic pollution leads to increased asthma ... this is due to increased blood levels of IL-17A, ... children with high diesel exposure. , The study by ... online in the Journal of Allergy and Clinical ...
... with the impact of climate change, archaeologists suggest we spare ... the last ice age. "The period scientists call the ... significant climatic event ever faced by humans on this continent," ... said. Research recently published in the Journal ...
... gobble up a baby placed in her arms, even ... everyone has noticed or felt, could have biological underpinnings ... international team of researchers has found evidence of this ... olfactory -- thus non-verbal and non-visual -- chemical signals ...
Cached Biology News:Climate change nothing new in Oz 2Why do you want to eat the baby? 2
Request Info...
QML offers standard and customized paraffin embedded tissue blocks....
... This service involves the ... optimization includes titration of the ... of secondary reagents (e.g. Alk. ... conjugates), optimization of detection, evaluation ...
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
Biology Products: