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arGEN-X advances ARGX-113 into preclinical development for autoimmune disorders
Date:4/24/2013

takes the progression of our pipeline to an exciting new level. In its broadest sense, we can envisage such a product potentially supplanting intravenous immunoglobulin (IVIG) in the treatment of autoimmunity. As well as the specific product potential of ARGX-113, we intend to outlicense our ABDEG technology to partners seeking to enhance therapeutic antibody potency in autoimmune disease. Furthermore, we see immediate applicability of ABDEGs in improving the efficacy of chronic disease treatment with biologics, including in the orphan drug space."

About ABDEG

ABDEG technology exploits the known binding interaction of antibody Fc regions with the    neonatal Fc receptor (FcRn), which is expressed in endothelial, hematopoietic and epithelial cells, and is central to the process of antibody clearance from the circulation. Based on specific mutations contained within the Fc domain, ABDEGs have several clear therapeutic applications with exciting development potential. The first, exemplified by ARGX-113, uses mutation-bearing Fc fragments as products for the treatment of autoimmune disorders. The second introduces the ABDEG mutations into therapeutic antibody product Fc regions, creating a dual therapeutic effect mediated by the binding of both variable and constant regions. The third promotes the active clearance of anti-therapy antibodies provoked in patients undergoing prolonged treatment with biologics, such as enzyme replacement or antibody-based therapies. For further information about ABDEGs, see Patel D.A. 2011. Neonatal Fc Receptor blockade by Fc engineering ameliorates arthritis in a murine model. The Journal of Immunology.187:1015-1022.

About arGEN-X

arGEN-X is a clinical stage human therapeutic antibody company that is rapidly developing a product pipeline using its unique suite of antibody technologies. arGEN-X is creating first and best in class antibody therapeutics with highly differentiated target prod
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