Professor Allan Young, Professor of Psychiatry at Imperial College London added: "Adherence is a big issue and contributes significantly to poorer outcomes in schizophrenia and bipolar disorder. The potential market for a weekly oral antipsychotic would likely be significant, and an accompanying "compliance" package would be welcomed by the community."
The recently granted U.S. Patent covers the treatment of psychotic conditions with orally-delivered formulations of aripiprazole that provide for sustained-release, once-weekly therapy. Patents have already been granted in Europe, Israel and Australia and applications are pending in Canada, South Korea and Japan. The new patent and related applications are all solely owned by Zysis.
1. Weiden PJ et al. Psychiatr Serv, 1995; 46: 1049-1054
2. Morken G et al. BMC Psychiatry, 2008; 8: 32-38
Notes to editors:
Zysis is a privately-owned specialty pharmaceutical company optimising therapies for disorders of the central nervous system (CNS). Zysis has reformulated aripiprazole, an effective antipsychotic molecule, to provide a patent-protected, sustained-release, once-weekly maintenance phase therapy in oral tablet form to improve clinical outcomes in schizophrenia and bipolar disorder therapy. Formulation development / initial Phase I studies have been successfully completed and the Phase II clinical programme has been established. Zysis is currently seeking funding to progress the phase II study either through licensing or by raising finance.
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