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ZARS Pharma Announces Marketing Authorization of Rapydan(R) in Europe
Date:2/27/2008

tion integrated with an oxygen-activated heating component (Controlled Heat-Assisted Drug Delivery system). When removed from the storage pouch, Rapydan begins to heat, warming the skin upon application. The heating component is intended to enhance the delivery of the local anesthetics into the skin and to provide vasodilation.

In clinical trials, the most common side effect was local skin reactions, such as erythema, edema, and blanching. Rapydan should not be used for a longer duration than recommended, and is contraindicated in patients with a known history of sensitivity to lidocaine, tetracaine or local anesthetics of the amide or ester type.

About ZARS Pharma

ZARS Pharma is a specialty pharmaceutical company focused on the development and commercialization of topically administered drugs using proprietary drug delivery technologies, primarily in the area of pain management and dermatology. ZARS Pharma has developed a rich portfolio of proprietary products and product candidates based on the CHADD technology and on cream technologies (Peel and DuraPeel(TM)) that transform, or phase-change, from an initial liquid phase to a solid phase during application. ZARS Pharma's product portfolio includes two products that have been approved for marketing (Pliaglis(TM) and Synera, latter marketed as Rapydan in Europe). ZARS Pharma currently has one product in a late-stage clinical trial that commenced in June 2007 (ThermoProfen(TM)) and four additional products that have entered various stages of clinical development. For more information on ZARS Pharma, please visit http://www.zars.com.

About EUSA Pharma

EUSA Pharma is a rapidly growing transatlantic specialty pharmaceutical company focused on inlicensing, developing and marketing late-stage oncology, pain control and critical care products. The company currently has six products on the market, including the antibiotic surgical implant Col
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SOURCE ZARS Pharma, Inc.
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