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YM BioSciences reports second quarter 2010 operational and financial results
Date:2/8/2010

Limited commenced enrollment of a Phase I/II trial evaluating CYT387, a potent, orally-administered JAK1/JAK2 inhibitor that is currently being conducted at Mayo Clinic in Rochester, MN. - Results showing that nimotuzumab in combination with metronomic chemotherapy (in frequent, low doses) in an advanced triple-negative breast cancer preclinical model is safe and effective, were presented in a poster at the 2009 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference in Boston, MA. - Results for CYT997 demonstrating that when administered metronomically, CYT997 is able to produce potent vascular disrupting effects in tumors (colon adenocarcinoma xenograft model), and in combination with cisplatin dosed weekly leads to enhanced antitumor effects compared to cisplatin alone, were presented in a poster by Cytopia Limited at the 2009 AACR-NCI-EORTC Molecular Targets and Cancer Therapeutics conference in Boston, MA. - Positive 48-month survival data for nimotuzumab were the subject of an oral presentation at the American Society for Therapeutic Radiology and Oncology (ASTRO) 2009 Annual Meeting in Chicago, IL. The trial was a randomized, four-arm study treating patients with inoperable, locoregionally-advanced, stage III/IVa head-and-neck cancer with radiation alone, chemoradiation alone, or radiation or chemoradiation in combination with nimotuzumab. - Additional results from a Phase III study in children with glioma, demonstrating that children and adolescents with this inoperable cancer were able to stay at home or attend school while undergoing treatment with nimotuzumab, were presented at the International Society of Paediatric Oncology (SIOP) in Sao Paulo, Brazil.

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On January 29, 2010
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