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YM BioSciences announces AACR acceptance of two nimotuzumab poster presentations
Date:3/15/2010

- University of Toronto results of nimotuzumab linked to radionuclide -

- Interaction of nimotuzumab with EGFRvIII, a mutant form of EGF receptor frequently expressed in brain tumors -

MISSISSAUGA, ON, March 15 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE YMI, TSX:YM), today announced that two posters have been accepted for presentation at the American Association for Cancer Research (AACR) Annual Meeting to be held from April 17-21 in Washington, DC. The first poster describes the results of the previously reported collaboration with researchers at the University of Toronto for the development of highly potent antibody-radionuclide conjugates for use in the treatment of cancer. The poster will describe activity of 111In-NLS-nimotuzumab against breast cancer cells with high and low EGFR expression. 111In-NLS-nimotuzumab was highly active against cells over-expressing EGFR whereas the nimotuzumab conjugate spared toxicity toward cells with EGFR expression similar to that on most normal epithelial cells.

The poster entitled "111In-NLS-Nimotuzumab: A potent Auger electron-emitting radiotherapeutic agent for EGFR-overexpressing breast cancer"
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SOURCE YM BioSciences Inc.
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