Navigation Links
YM BioSciences Reports Positive Interim Data Including Substantial Anemia Response from Phase I/II Trial of JAK1/JaK2 Inhibitor CYT387
Date:12/6/2010

ORLANDO, FL, Dec. 6 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI; TSX: YM) today announced positive interim data from the first 60 patients enrolled in the Phase I/II trial for its JAK1/JAK2 inhibitor, CYT387, in myelofibrosis. The results were reported today in an oral presentation at the 52nd American Society of Hematology (ASH) Annual Meeting being held in Orlando, Florida.

"Anemia is the most serious symptom associated with myelofibrosis, so I am highly encouraged by the emerging activity profile of CYT387, which uniquely continues to demonstrate a substantial ability to improve anemia while producing similar results to its peers in reducing spleen size and controlling constitutional symptoms," noted Dr. Alayew Tefferi, Chair of the Study. "I also encourage YM to evaluate CYT387 in other diseases where anemia has a significant impact."

"These unprecedented results highlight the potential safety and efficacy advantages of CYT387 compared with other JAK inhibitors. If CYT387 continues to demonstrate this unique anemia benefit in larger trials, it may ultimately serve as a drug of choice for the majority of patients with myelofibrosis who find anemia problematic," said Dr. Nick Glover, President and CEO of YM BioSciences. "We look forward to updated data from the full 140 patient trial in calendar mid-2011."

Patient Characteristics:

The presentation described interim results for the first 60 patients enrolled in the dose escalation (n=21) and dose confirmation (n=39) portions of the 140 patient Phase I/II trial, for which recruitment is ongoing. In the dose-confirmation phase, subjects were started at one of two dose levels that were deemed clinically effective: 150 mg/day (n=18) and 300 mg/day (n=21). Thirty-three subjects (55%) were red cell transfusion-dependent at study entry. Forty-five subjects (75%) expressed the JAK2V617F mutation.
'/>"/>

SOURCE YM BioSciences Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387
2. Ardea Biosciences to Present at Two Upcoming Investor Conferences
3. YM BioSciences Reports Fiscal First Quarter 2011 Operational and Financial Results
4. YM BIOSCIENCES REPORTS SIGNIFICANT RESPONSE RATES IN ANEMIA, SPLENOMEGALY, AND CONSTITUTIONAL SYMPTOMS FROM THE PHASE I/II TRIAL OF ITS JAK1/JAK2 INHIBITOR, CYT387, IN MYELOFIBROSIS
5. Regado Biosciences Awarded Three Grants from the Federal Government to Advance Research of Lead Programs
6. Sangamo BioSciences Awarded Grants for the Development of Four ZFP Therapeutic® Programs
7. Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act
8. X-BODY BioSciences Awarded Grant for Therapeutic Discovery Project Targeting Metastatic Tumor Stem Cells
9. Ardea Biosciences to Present at the Oppenheimer 21st Annual Healthcare Conference
10. Regado Biosciences to Present at the Oppenheimer 21st Annual Healthcare Conference in New York City
11. GeneLink BioSciences, Inc. Ranked 62nd Fastest Growing Company in North America on Deloittes 2010 Technology Fast 500â„¢
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... 2014 Synageva BioPharma Corp. ... company developing therapeutic products for rare disorders announced ... as Chief Operating Officer.  Reporting directly to ... Officer, Robert will oversee the planned global commercial ... for LAL Deficiency, and will have responsibility for ...
(Date:9/21/2014)... Chemical Sciences play a significant role in meeting ... safe water, healthy food, and dependable medicine from ... educators, and scientists have a great role in ... for the national development, and to foster research ... emerging Sciences, accelerating with a tremendous speed to ...
(Date:9/19/2014)... BRISBANE, Calif., Sept. 19, 2014  InterMune, Inc. (Nasdaq: ... into a Memorandum of Understanding to settle the litigation ... Agreement and Plan of Merger dated as of August ... and InterMune, Inc.  As one term of the Memorandum ... disclosures set forth in the attached exhibit reflecting the ...
(Date:9/19/2014)... 19, 2014 Follow us ... to revolutionize the world has attracted diverse players ... small start-ups. The early years of nanotechnology development ... due to the high risks involved, which deterred ... for this evolving technology have been growing over ...
Breaking Biology Technology:Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 2Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 3Synageva BioPharma Appoints Robert Bazemore As Chief Operating Officer 4Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4
... ... and sharing of NGS runs; free 2-hour seminar, includes lunch and roundtable discussion, ... (Vocus) February 15, ... ,Learn about sequence data management and the GenomeQuest interactive, web-based tools for comparison, querying, ...
... PHILADELPHIA - Material scientists at the Nano/Bio Interface ... the transduction of optical radiation to electrical current ... of nano-sized molecules of gold, respond to electromagnetic ... project electrical current across molecules, similar to that ...
... ... loving." , ... (PRWEB) February 12, 2010 -- On February 14th, online problem-solving platform ... any discipline and research function—presently employed by an organization, public or private—are invited ...
Cached Biology Technology:GenomeQuest Announces Boston Seminar: Sequence Data Management for Next Generation Sequencing 2Penn material scientists turn light into electrical current using a golden nanoscale system 2No Plans for Valentine's Day? Learn to Love Problems, Says hypios 2
(Date:9/22/2014)... More than 7,000 geoscientists will gather in Vancouver, ... Geological Society of America,s 126th Annual Meeting & Exposition ... topics as the transportation of crude oil, earthquake prediction ... field guide, Trials and Tribulations of Life on an ... the Vancouver area. , A broad range of topics ...
(Date:9/21/2014)... the University of California, San Diego, have developed a ... control the activity of genes based on sequences of ... its application to human embryonic cells in a paper ... , "All of our cells have the same blueprint, ... John Whitaker, lead author of the report. "Skin cells ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
Breaking Biology News(10 mins):Geoscience topics in the spotlight -- Vancouver, BC 2Geoscience topics in the spotlight -- Vancouver, BC 3Geoscience topics in the spotlight -- Vancouver, BC 4Geoscience topics in the spotlight -- Vancouver, BC 5Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2
... new study reveals that governments in Latin America have ... scant attention to the impact mining, oil exploration and ... people who own the land. The study, which reported ... the 14th Rights and Resources Initiative Dialogue on Forests, ...
... WHAT: Biologist Mary Gehring, Ph.D. is The Pew ... her creative research on epigenetics in plants. Using the ... embryonic development, Gehring,s lab at the Whitehead Institute for ... which genes are turned on and off in seeds. ...
... 21, 2013 Reportlinker.com announces that a ... its catalogue: Global ... This report analyzes the ... Thousands by the following Product Segments: Automated ...
Cached Biology News:Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 2Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 3Study shows resources giveaway in Latin America; Outdated model tramples human rights, environment 4Global Fingerprint Biometrics Industry 2Global Fingerprint Biometrics Industry 3Global Fingerprint Biometrics Industry 4Global Fingerprint Biometrics Industry 5Global Fingerprint Biometrics Industry 6Global Fingerprint Biometrics Industry 7Global Fingerprint Biometrics Industry 8Global Fingerprint Biometrics Industry 9Global Fingerprint Biometrics Industry 10Global Fingerprint Biometrics Industry 11Global Fingerprint Biometrics Industry 12Global Fingerprint Biometrics Industry 13Global Fingerprint Biometrics Industry 14Global Fingerprint Biometrics Industry 15Global Fingerprint Biometrics Industry 16Global Fingerprint Biometrics Industry 17Global Fingerprint Biometrics Industry 18Global Fingerprint Biometrics Industry 19
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
Biology Products: