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YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387
Date:11/18/2010

lopment of a drug that could help these patients," said Dr. Jason Gotlib, Assistant Professor, Department of Medicine (Hematology), Stanford University Medical Center.

CYT387 was granted Orphan Drug Designation by the US FDA in September.

For more information on the CYT387 Phase I/II trial, please go to:
cr="true" href="http://clinicaltrials.gov/ct2/show/NCT00935987?term=cyt387&rank=1">http://clinicaltrials.gov/ct2/show/NCT00935987?term=cyt387&rank=1 Oral Presentation at the 52nd American Society of Hematology Annual Meeting: An oral presentation of the CYT387 Phase I/II results will be delivered by Dr. Pardanani on Monday, December  6, 2010 at 11:15 AM in the Orange County Convention Center, Valencia B/C as part of the session named Myeloproliferative Syndromes: Clinical and Translational Advances in Myeloproliferative Neoplasms. YM will host a conference call following the presentation to discuss the trial results. About YM BioSciences YM BioSciences Inc. is a drug development company advancing three clinical-stage products: CYT387, a small molecule, dual inhibitor of JAK1/JAK2 kinase; nimotuzumab, an EGFR-targeting monoclonal antibody; and CYT997, a potent vascular disrupting agent (VDA).

CYT387 is an orally administered inhibitor of both the JAK1 and JAK2 kinase enzymes, which have been implicated in a number of immune cell disorders including myeloproliferative disorders and inflammatory diseases as well as certain cancers. CYT387 is currently in a Phase I/II trial in myelofibrosis with detailed initial safety and activity data expected at the American Society of Hematology (ASH) meeting in December 2010. Nimotuzumab is a humanized monoclonal antibody targeting EGFR with an enhanced side effect profile. Nimotuzumab is being evaluated in numerous Phase II and III trials worldwide by YM's licensees. CYT997 is an orally-available smal
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SOURCE YM BioSciences Inc.
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