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YM BioSciences Expands Phase I/II Trial for JAK Inhibitor CYT387
Date:11/18/2010

emonstrates the tolerability and durability of response our drug has produced so far," said Dr. Nick Glover, President and COO of YM BioSciences. "We anticipate this trial will be fully enrolled in the first calendar quarter of 2011 and that interim data from the fully-enrolled Phase II portion of the study will be available in mid-2011. We also look forward to the presentation of detailed results from the first 60 patients treated in the Phase I and early Phase II portion of this trial at the American Society of Hematology conference in early December 2010."

Furthermore, subject to regulatory approval, the trial will be expanded from 120 patients to 140 patients to include a 20-patient cohort to be dosed twice-daily at 150mg per dose. "Since we have seen encouraging efficacy signals at the 150 mg and 300 mg once daily dosing levels, it is clearly worthwhile to explore this additional dosing schedule," added Dr. Glover.

In addition to the Stanford Cancer Center, the Company anticipates patients will shortly be enrolled at the Royal Melbourne Hospital (Melbourne, Australia) under Principal Investigator Andrew Roberts, MD; at Princess Margaret Hospital (Toronto, Canada) under Principal Investigator Vikas Gupta, MD; and at the Jewish General Hospital (Montreal, Canada) under Principal Investigator Shireen Sirhan, MD. It is likely that additional clinical centers will join the program in the coming months.  The Phase I/II trial was initiated in November 2009 at Mayo Clinic (Rochester, Minnesota) under Principal Investigator Animesh Pardanani, MD with Ayalew Tefferi, MD as Chair.

"Early data for CYT387 has shown it is capable of reducing spleen size and controlling the constitutional symptoms of myelofibrosis and, importantly, may also provide the additional benefit of improving anemia in these patients. As there are no approved treatments in the United States for this disease, we welcome the opportunity to participate in the clinical deve
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SOURCE YM BioSciences Inc.
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