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YM BIOSCIENCES REPORTS 2007 YEAR END OPERATIONAL AND FINANCIAL RESULTS
Date:9/23/2007

ear:

- YM USA was cleared by the US FDA to expand its second-line clinical

trial in children with inoperable, recurrent, treatment-resistant

brain cancer into the US

- Oncoscience AG reported completion of patient enrolment in the

Phase III, first-line, pediatric brain cancer trial.

- Oncoscience AG reported initiation of late-stage trials in adult

glioma and pancreatic cancer.

- YM reported positive preliminary results of a Phase I/II trial of

nimotuzumab in combination with radiation for the treatment of

non-small-cell lung cancer (NSCLC).

- The first 20 patients were recruited into the Phase II colorectal

trial by the date of this release.

AeroLEF(TM):

AeroLEF(TM) is a unique, inhaled-delivery composition of free and liposome-encapsulated fentanyl in development for the treatment of moderate to severe pain, including cancer pain. AeroLEF(TM) permits patients to identify and select the appropriate dose in real-time for each pain episode to achieve both rapid onset and extended duration of analgesia.

During Fiscal 2007:

- YM announced that AeroLEF(TM) had met the primary endpoint in its

first randomized, placebo-controlled Phase IIb trial enrolling opioid-

naive patients with post-operative pain following orthopedic surgery.

A statistically significant difference in pain relief and pain

intensity to placebo (p=0.0194) was reported.

- YM received clearance from the FDA to initiate a Phase II trial in the

US in opioid tolerant or opioid-naive patients. A successful trial

would further extend the utility and medical breadth of the product if

and when approved. Enrollment in its 50-patient trial is expected to

start in calendar Q4, 2007.

- A request to the FDA for an End-of-Phase II meeting prior to calendar

year-end 2007 to discuss Phase III trial desi
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SOURCE YM BioSciences Inc.
Copyright©2007 PR Newswire.
All rights reserved

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