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Xention Reports Positive Phase 1 Data for New Atrial Fibrillation Drug
Date:3/20/2012

eveloper of highly selective ion channel drugs for the treatment of atrial fibrillation.  Utilising its world-leading expertise in the discovery of potent and selective drugs, Xention is focusing on the potassium channels Kv1.5 and IKACh which are widely recognised by cardiologists as the preferred targets for the prevention of atrial fibrillation.  Xention's lead drug candidate XEN-D0103, a Kv1.5 antagonist, is at the end of phase 1 clinical development and has demonstrated a very high degree of selectivity over non-atrial ion channels.  The company has also developed antagonists of IKACh which are highly potent and selective, and an IKACh development candidate will be selected shortly.

Xention has signed two major research collaborations with Ono Pharmaceutical Co Ltd and the Grϋnenthal Group, which take advantage of its strong experience in ion channel discovery and which are focused on the development of clinical candidates in other therapeutic areas.

Xention is based in Cambridge, UK and employs over 50 people. For further information, please visit http://www.xention.com.

For further information, please contact:

Tim Brears, CEO, Xention Limited, +44(0)1223-493-900

Amber Bielecka / Claire Dickinson, M:Communications, xention@mcomgroup.com, +44(0)20-7920-2352


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