Navigation Links
Xencor's XmAb5871 Enters Phase 2a Study for Autoimmune Disease
Date:10/1/2013

MONROVIA, Calif., Oct. 1, 2013 /PRNewswire/ -- Xencor, Inc. today announced that the first patient has been dosed in the Phase 2a part of its ongoing Phase 1b/2a clinical trial of XmAb®5871 in patients with active rheumatoid arthritis. XmAb5871 is the first in Xencor's class of therapeutic antibodies targeting the FcγRIIb pathway in B cells, which shows potential to suppress autoimmune disorders without the side effects caused by B cell depletion.

XmAb5871 is an Fc engineered monoclonal antibody that inhibits B cells by dual targeting CD19 and FcγRIIb. Amgen Inc. and Xencor entered into a collaboration and option agreement for XmAb5871 in December 2010. Under that agreement, Amgen has the option to acquire an exclusive worldwide license to XmAb5871, exercisable at any time before completion of a data review period following our planned subsequent Phase 2b proof-of-concept clinical trial. Xencor leads all research, development, and manufacturing activities for XmAb5871 until that time and is eligible for milestone payments.

"XmAb5871 represents a novel therapeutic strategy for engaging the FcγRIIb pathway to suppress autoimmune responses without B-cell depletion," said Bassil Dahiyat, Ph.D., president and CEO of Xencor. "This Phase 2a rheumatoid arthritis data is intended to inform a larger Phase 2 study and may support the potential use of XmAb5871 in other autoimmune diseases, such as lupus."

The Phase 2a portion of the clinical trial will evaluate biweekly doses of XmAb5871 in approximately 30 rheumatoid arthritis patients with active disease on stable non-biologic DMARD therapy. Endpoints include clinical markers of disease response.

XmAb5871 was well tolerated in the Phase 1a dose escalation part of the trial that enrolled 48 healthy male subjects and inhibited multiple biomarkers of immune function.

About Xencor, Inc.

Xencor is developi
'/>"/>

SOURCE Xencor, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Sacom SPA, Leader in the Italian Green Biotechnology Fertilizer Industry, Enters the VedoGreen Financial Network
2. U.S. Blood Centers Pursue an Evolving Role in Cell Therapies
3. Blood Centers of America Experiences Record Growth
4. Verenium Enters Agreement To Be Acquired By BASF
5. CCG Investor Relations Announces Company Presenters for NexGen Life Sciences Virtual Conference
6. Independent Living Centers Play A Vital Role In Helping Students Transition Out Of High School
7. Curemark Enters into Research Collaboration with The Molecular Sciences Institute (VTT/MSI)
8. Gallus BioPharmaceuticals Enters Clinical Supply Agreement with Genzyme for Niemann-Pick Type B Disease
9. Inflamax Research Inc. Enters Strategic Partnership with Northern Air Environmental Technologies Inc.
10. 7 SynCardia Certified Centers Honored Among “Best Children’s Hospitals” for Cardiology and Heart Surgery by U.S. News & World Report
11. VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... 2015 The American Brain Tumor Association (ABTA) ... Discovery Research Grant program. LOIs are due no later ... Discovery Grants are one-year, $50,000 grants that ... change current diagnostic or treatment paradigms for adults and ... research at its earliest stages, in the hopes that ...
(Date:9/1/2015)... ... ... In her thought provoking debut novel ‘ Ebola Vaccine Wars ’ (eBookIt.com; ... an Ebola pandemic that is on the cusp of wiping out humanity. Venice introduces ... counterterrorism, and who continues to appear in this series of books by Venice. ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... biopharmaceutical companies in the neuro and pain management space join prominent academics and ... Martin Conference Center at Harvard Medical School in Boston. , Neuro Advance ...
(Date:9/1/2015)... ... September 01, 2015 , ... A ... discovered by researchers at the Keck Graduate Institute and its collaborators. The discovery ... The findings were published online on August 27 by Scientific Reports, an open ...
Breaking Biology Technology:American Brain Tumor Association Seeks Innovative Concepts For Discovery Research Grants 2Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 2Alexi Venice’s Debut Novel Takes on the Human Testing of a Vaccine for Ebola and Revenge by an Anti-Big Pharma Terrorist Group in ‘Ebola Vaccine Wars' 3Neuro Advance Boston Brings Together Leading Neuroscience Experts on October 14 at Harvard Medical School 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4
... the aim of a new licensing deal between the ... and the company, based in West Sacramento, Calif., have ... of jointly-owned intellectual property stemming from inventions both on ... enable manufacture of very thin, very small wires, films ...
... Incorporated,(Nasdaq: GPRO ) announced today that the Company ... results on Wednesday, February 13,2008 at approximately 4:00 p.m. ... conference call at 4:30 p.m. ET hosted by Henry ... Rosenman, senior,vice president, finance, and chief financial officer., ...
... Inc.,(Amex: PIP ) a biodefense company developing ... the Delaware Chancery Court,today issued a ruling denying ... which alleges that it has a right to ... candidate, SIGA-246. SIGA,s,request to dismiss the claim by ...
Cached Biology Technology:Solar energy technology licensed 2Gen-Probe Announces Webcast of Fourth Quarter and Full Year 2007 Earnings Conference Call 2Delaware Court Denies Motion by SIGA Technologies Seeking to Dismiss PharmAthene's Legal Action in Breach of Contract Lawsuit Against SIGA 2
(Date:8/12/2015)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is proud to announce that iMedNet ... platform, has led the way to significant and unprecedented ...   Q2 2015 and Q1 2015 were, respectively, the ... sold in the company,s 15 year history.  In addition, ...
(Date:8/12/2015)... , Aug. 12, 2015  New research unveiled ... attack Android phones to steal users, fingerprints. Information ... availability of fingerprint scanners on mobile devices, making ... To secure biometrics on mobile devices, HYPR Corp. ... these convenient authentication systems with strong cryptographic security. ...
(Date:8/11/2015)... , August 11, 2015 Today, ZUK announced ... received as well as expected revenues in 2015 that relate to ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ... a prominent smartphone manufacturer in ... selected FPC1 155 for ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... Medical Center will present techniques and discuss surgical approaches ... the American Association of Neurological Surgeons (AANS), held April ... The Department of Neurosurgery at NYU Langone ... top ten hospitals in the country for neurology and ...
... University of Maryland Solar Decathlon Team has unveiled its entry ... structure they call WaterShed, because it integrates a unique array ... of the Chesapeake Bay. The unveiling ceremony brought together ... make up the Maryland team, one of only 20 finalists ...
... theory that early human ancestors in East Asia crafted their ... originally conceived, according to a new study. Research until ... even possible to make complex bamboo tools with simple stone ... a modern-day flint knapper replicated the crafting of bamboo knives ...
Cached Biology News:NYU Langone experts present advances at American Association of Neurological Surgeons Meeting 2UMD Solar Decathlon team unveils 'WaterShed' 2UMD Solar Decathlon team unveils 'WaterShed' 3Scientists make bamboo tools to test theory explaining East Asia's Stone Age tool scarcity 2Scientists make bamboo tools to test theory explaining East Asia's Stone Age tool scarcity 3Scientists make bamboo tools to test theory explaining East Asia's Stone Age tool scarcity 4
Dopamine D2 and D3 receptor, human and possibly mouse. AB1502 detects 40 ng of dopamine receptor peptide by ELISA. AB1502 is not neutralizing....
STX18 Immunogen: STX18 (NP_058626, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Mouse monoclonal [CLB-SW16 (formerly 708)] to CD42d (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 2814 SwissProtID: P40197...
Request Info...
Biology Products: