Navigation Links
X-ray laser helps fight sleeping sickness
Date:12/4/2012

te.

Two recent developments allowed them to overcome this problem: a new way to grow crystals of the enzyme for analysis and the ability to analyze those tiny crystals with the LCLS X-ray laser, whose pulses are so intense and fast that they capture structural information before a sample is damaged.

The researchers grew the crystals inside live insect cells, freezing the enzyme in its natural inhibited state. Then they streamed the crystals into the laser's path, producing patterns in a detector that were used to reconstruct the enzyme and its inhibitor in 3-D and at nearly atomic scale.

"In my opinion, we provided the most complete blueprint available so far for the development of a synthetic inhibitor to block this enzyme," Redecke said. "Whether it will be successful is hard to say, but the odds are significantly increased by this structural data."

Redecke said his research team is working to crystallize proteins relevant to other parasites and viruses, including strains of hepatitis and flu, that could also be studied at LCLS, and he expects this field of research to grow.

"Our study will encourage others to use free-electron lasers to obtain new structural information of biologically relevant molecules," Redecke said.


'/>"/>

Contact: Andy Freeberg
afreeberg@slac.stanford.edu
650-926-4359
DOE/SLAC National Accelerator Laboratory
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. CU-Boulder physicists use ultrafast lasers to create first tabletop X-ray device
2. X-ray vision exposes aerosol structures
3. Advance in X-ray imaging shines light on nanomaterials
4. Eye Surgery Center of Michigan First in Southeast Michigan to Perform Bladeless Cataract Surgery Using New LenSx® Laser Technology
5. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
6. Research could improve laser-manufacturing technique
7. Cooling semiconductor by laser light
8. New laser can point the way to new energy harvesting
9. Metamaterials may advance with new femtosecond laser technique
10. UCSB Physicists mix 2 lasers to create light at many frequencies
11. JPSA Introduces Picosecond Laser Micromachining System
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
X-ray laser helps fight sleeping sickness
(Date:12/22/2014)... 2014  ( www.competitivehealth.com ) — Competitive Health is ... review and advocacy service, has signed an agreement to ... discount health services marketplace. 63% of Americans ... they expected to pay. As part of an ongoing ... Savings is pleased to offer medical bill review and ...
(Date:12/22/2014)... ITRA Global, one of the largest ... real estate, has further expanded its global reach with ... Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman of ... Global / ACORPP (Australian Corporate Property and Projects) , ... property services to a wide range of clients in ...
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... 2014 BioPlus Specialty Pharmacy ... the promotion of Nick Maroulis, Pharm.D. to the newly ... , In this position, Dr. Maroulis will continue ... the directors of our multi-site pharmacies as the company ... and during that time he has served in many ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2
... Court Enters Consent Judgment Terminating Litigation --, ... WYE ) and,Impax Laboratories Inc. today announced that ... infringement litigation pertaining to Impax,s proposed,generic capsule formulation ... the United States District Court for the District ...
... announced,today that it has initiated coverage on MediciNova ... drug development pipeline for treating a,variety of diseases ... two,drug development programs; the first is MN-221 for ... 2,000,000 visits to the emergency room,a year for ...
... International,Corporation (Nasdaq: PRXL ), a leading global ... Mark A. Goldberg, M.D.,to Chief Operating Officer (COO). ... Services and Perceptive Informatics at,PAREXEL. He will continue ... report,to Josef von Rickenbach, Chairman and Chief Executive ...
Cached Biology Technology:Wyeth and Impax Announce Final Settlement of Effexor XR Patent Suit 2Wyeth and Impax Announce Final Settlement of Effexor XR Patent Suit 3Vista Partners Initiates Coverage on MediciNova Inc. (Nasdaq: MNOV) 2PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 2PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 3PAREXEL Promotes Dr. Mark A. Goldberg to Chief Operating Officer 4
(Date:12/19/2014)... DUBLIN , Dec. 18, 2014 Research and ... addition of the "Micro Market Monitor: North America ... http://photos.prnewswire.com/prnh/20130307/600769 ... grow at a CAGR of 3.6% from 2014 to ... in this market, Canada is ...
(Date:12/17/2014)... 15, 2014 Research and Markets ... the "Samsung Galaxy S5 - Home Button ... their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... sensing technology than the iPhone 5S, Samsung introduces ... its product. The Galaxy S5 home ...
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ... robust – with the clinical data to back it ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2
... generation really occur thousands of years ago" Was the Roman ... levels in our deep seas remain forever a mystery" ... are being addressed by a new environmental marine research team ... organization, EcoOcean. The team, headed by EcoOcean,s Andreas ...
... In work that could lead to safe and effective techniques ... fine-tune the ability of biodegradable polymers to deliver genes. ... to fight diseases like cancer, holds great promise but has ... safety concerns over the conventional technique of using viruses to ...
... Kingdom of Saudi Arabia (September 5, 2007) King ... American University in Cairo (AUC) signed a Memorandum ... research and academic development that will positively impact the ... A. Al-Nasr, interim president of KAUST, and Dr. David ...
Cached Biology News:TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 2TAU scientists probe 'deep' questions aboard EcoOcean's environmental research ship 3MIT works toward safer gene therapy 2KAUST and American University in Cairo to collaborate on research and academic development 2
... formulated specifically for Alkaline Phosphatase conjugates. ... activity for both the enzyme and the ... This product has been chemically engineered ... a longer shelf life, resistance to various ...
... The PATH™ Protein Microarray Slide features ... immunoassays. The,PATH™ Slide is the first ... many benefits of nitrocellulose in a ... excellent signal-to-noise ratios. ,The PATH™ ...
... Cassettes facilitate the hybridization of DNA or ... 25mm x 75mm glass slides. The proprietary ... correct for poor flatness, as is often ... low volume chamber (67uL analytical cavity volume) ...
... Mouse monoclonal [3D12] to Lambda Free ... Mixture of light chains of human ... for independent constantly expressed epitope of ... dimer forms of free lambda chains ...
Biology Products: