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World's Top Gene Synthesis Companies Establish Tough Biosecurity Screening Protocol
Date:11/19/2009

elivery of synthetic DNA by implementing strong internal biosecurity practices,” said Dr. Ralf Wagner, CEO and CSO of GENEART. “We hope that the IGSC will help to encourage effective collaboration with government and policy organizations and promote internationally consistent approaches to safety and security in gene synthesis.”

“Each of the IGSC companies have worked over the past several years to implement internal sequence and customer screening processes, while contributing to the larger conversation amongst government agencies, policy organizations and the broader scientific community about developing an internationally coordinated approach to biosecurity,” said Nick Yan, Vice President, Marketing of GenScript USA. “Recognizing that achieving real gains in biosecurity requires harmonization of screening and other practices, we have drafted a harmonized screening protocol and decided to form the IGSC in an effort to coordinate ongoing work toward shared best practices in the gene synthesis industry."

The IGSC’s “Harmonized Screening Protocol for Gene Sequence & Customer Screening to Promote Biosecurity” establishes the five core components that each IGSC company will apply to promote the safe use of synthetic genes:

 
  • Gene Sequence Screening: The complete DNA sequence of every synthetic gene order is to be screened against a Regulated Pathogen Database developed by the consortium and one or more of the internationally coordinated sequence reference databanks (i.e., NCBI/GenBank, EBI/EMBL or DDBJ). Amino acid sequences of possible translation products for each synthetic gene o
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