Navigation Links
Worcester Polytechnic Institute Receives NIH Grant to Study Components of a Potentially Potent and Cost-Effective Malaria Treatment
Date:7/15/2014

pal therapeutic compound in the plant, is extracted, purified, and combined with other drugs to make ACT. Weathers’s team takes a different approach, using dried whole leaves from Artemisia annua as a medication.

In previous work Weathers and her colleagues have shown that mice fed powered dried leaves had 40 times more artemisinin in their blood stream than mice fed pure artemisinin. Furthermore, the whole-plant therapy was five times more effective in clearing the disease-causing parasite from the mice. In addition to delivering more artemisinin to the bloodstream, the effectiveness of the whole plant treatment may be due to the presence of other potentially therapeutic compounds in the leaves.

In the new study, Weathers will use a laboratory model of the human digestive system to discover which compounds in the leaves move through the intestinal wall. She will focus on several compounds, including flavonoids and terpenes, which have exhibited antimalarial effects of their own and which may also help artemisinin move through the intestinal wall and into the bloodstream where it can attack the malaria parasite.

Flavonoids are widely distributed in plants and have various functions, including giving blossoms color. They are also believed to work synergistically with artemisinin to kill the malaria parasite. Terpenes are among the essential oils that play a role in the plant’s defense system. Secreted terpenes have anti-microbial properties and deter some leaf-eating predators.

In a series of experiments over the next three years, the Weathers lab will use a cell culture model to study how the flavonoids and terpenes move through a layer of cultured human intestinal wall cells. They will also test the flavonoids and terpenes in combination with artemisinin to see how they affect the movement of artemisinin across the cell layer.

“Because these other compounds in the plant have some therapeutic activity, using the whole plant be
'/>"/>

Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Averica Discovery Services and Worcester Polytechnic Institute Establish Research Collaboration
2. Worcester Polytechnic Institute’s Tanja Dominko Named Slovenian Ambassador of Science for 2013
3. Masaryk Memorial Cancer Institute Reduces Losses and Administrative Overhead With Ekahau RTLS
4. Van Andel Institute Partners with UNCF to Recruit Students to Biomedical Research Careers
5. The Pharmabiotic Research Institute (PRI) is Preparing to Publish its First Works on the Therapeutic and Medicinal Potential of Probiotics
6. Michael A. Marletta Takes Office as New President of Scripps Research Institute
7. HealthCare Institute of New Jersey Releases 2011 Biopharmaceutical and Medical Technology Economic Impact Data
8. QIAGEN and Max Planck Institute for Infection Biology Collaborate to Develop Assay for Active TB Risk in Individuals With Latent Infection
9. DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs
10. Niels Bohr Institute gets top researcher from Harvard
11. Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 2015  Guggenheim Securities, the investment banking and capital ... of William Tanner as a Managing Director ... will start work at Guggenheim in May 2015 in ... "Bill brings a wealth of biotech experience, ... and highly acclaimed healthcare team," said Matthew Johnson ...
(Date:4/16/2015)... Carolina (PRWEB) April 17, 2015 ... steam system services, released their newly designed, state-of-the-art ... The customer facing website effectively promotes the Spirax ... , All the information that a site visitor ... system services, company capabilities, industries serviced, the latest ...
(Date:4/16/2015)... Proove Biosciences , Inc. is pleased ... for the 2015 BIO International Convention. Hosted by ... Convention will take place June 15-18 at the Pennsylvania ... BIO contest, industry leaders will be voting for companies ... The community voting period began on April 14, 2015 ...
(Date:4/16/2015)... 16, 2015 The Council for ... prestigious 2015 Borlaug CAST Communication Award goes to ... Tuskegee University in Alabama. Award nominees must demonstrate ... presentations; and/or the use of television, radio, or ... areas. As a specialist in the field of ...
Breaking Biology Technology:Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2Spirax Sarco website has a new look 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2
... , DOYLESTOWN, Pa., Sept. 17 Following the ... , the novel self-expanding coronary stent system will be the ... coronary artery disease at TCT 2009 , September ... device, also from Prescient Medical , will be ...
... , BETHESDA, Md., Sept. 17 Micromet, Inc. ... proprietary antibodies for the treatment of cancer, inflammation and autoimmune ... and webcast on September 22, 2009 at 7:00 am U.S. ... clinical trial with Micromet,s anti-EpCAM BiTE antibody MT110, which was ...
... , BOULDER, Colo., Sept. ... been awarded two Phase I Small Business Innovation Research (SBIR) ... and Infectious Diseases (NIAID) of The National Institutes of Health ... preclinical toxicology and pharmacology studies of the company,s proprietary long-acting ...
Cached Biology Technology:TCT 2009 to Feature vProtect(TM) Luminal Shield, a Novel Treatment Designed for Soft Coronary Lesions from Prescient Medical 2Micromet to Host Conference Call and Webcast to Discuss MT110 Data Presented at ECCO/ESMO on September 22, 2009 2Micromet to Host Conference Call and Webcast to Discuss MT110 Data Presented at ECCO/ESMO on September 22, 2009 3Bolder BioTechnology Receives $1.2 Million from NIH to Study Long-Acting G-CSF and GM-CSF Analogs in Treating Acute Radiation Syndrome 2
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ( ... Voice Biometrics - Global Strategic Business Report" report to their ... and Voice Biometrics in US$ Thousands by the following Segments: Face ... the US, Canada , Japan ... Middle East & Africa ...
(Date:3/23/2015)... BOSTON, Mass , March 23, 2015 SoundView ... shipment of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView ... world user feedback on their experience with the Wocket in ... experience at CVS, Whole Foods and other retailers, making both ... Kris Tuttle also says, "If the company meets ...
(Date:3/23/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... television starting March 30 th . ... New York markets. ... about our new ad campaign following the recent initial shipment ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... Sometimes the best discoveries come by accident., A ... Louis, headed by Srikanth Singamaneni, PhD, assistant professor ... the mechanism by which tiny single molecules spontaneously ... for a different experiment in the refrigerator., Once ...
... at Ume University in Sweden conclude that public opposition to ... sometimes argued in dam removal science. It is instead a ... the functions it provides. The findings are now published in ... is an increasingly common practice as old splash dams and ...
... the costs and benefits of plastic vegetable greenhouses ... inside plastic greenhouses, particularly for small-holders, have driven ... farmlands worldwide but particularly in China, where ... US $60 million in produce (2008 figures). The ...
Cached Biology News:Watching molecules grow into microtubes 2Controversial dam removals founded on value conflicts 2February highlights from Ecological Society of America publications 2February highlights from Ecological Society of America publications 3February highlights from Ecological Society of America publications 4
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
Collected from normal, healthy animals in carefully maintained standing herds of US orgin. Pricing: $45/unit for 1 - 10 units...
NORMAL DONOR DONKEY SERUM...
Whole blood is collected from canines (any breed, either sex), refrigerated within 6 hours, processed within 24 hours and frozen at -20C....
Biology Products: