Navigation Links
Why stem cells need to stick with their friends
Date:11/7/2013

Scientists at University of Copenhagen and University of Edinburgh have identified a core set of functionally relevant factors which regulates embryonic stem cells' ability for self-renewal. A key aspect is the protein Oct4 and how it makes stem cells stick together. The identification of these factors will be an important tool in devising better and safer ways of making specialised cells for future regenerative cell therapies for treatment of diseases like diabetes and Parkinson's disease. The results have just been published in the scientific journal Current Biology.

Scientists have known that the protein Oct4 plays a key role in maintaining the embryonic stem cells in pure form by turning on stem cell genes, however up until now it has not been know which of the 8.000 or more possible genes that Oct4 can choose from actually support self-renewal.

By comparing the evolution of stem cells in frogs, mice and humans, scientists at the Danish Stem Cell Center (DanStem) and The MRC Centre for Regenerative Medicine in Edinburgh have now been able to link the protein Oct4 with the ability of cells to stick together. They found that for embryonic stem cells to thrive they need to stick together and Oct4's role is to make sure they stay that way.

"Embryonic stem cells can stay forever young unless they become grown-up cells with a specialised job in a process called differentiation. Our study shows that Oct4 prevents this process by pushing stem cells to stick to each other," says Dr Alessandra Livigni, Research Fellow at the University of Edinburgh.

Identification of specific genes

The research teams in Edinburgh and Copenhagen successfully identified 53 genes, out of more than 8.000 possible candidates that together with Oct4, functionally regulate cell adhesion. Almost like finding needles in a haystack the scientists have paved the way for a more efficient way of maintaining stem cells as stem cells.


'/>"/>

Contact: Joshua Brickman
Joshua.brickman@sund.ku.dk
45-51-68-04-38
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Student at Cleveland’s University School Conducts Research on the Role of Hair Cells in Hearing
2. Small Cells and Femtocells Market Shares, Strategies, and Forecasts, Worldwide, 2013 to 2019 New Market Research Report Available on Researchmoz.us
3. Adaptive Biotechnologies Publishes Gold Standard Method for Sequencing Cells of the Adaptive Immune System
4. Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells Industry Trend: Worldwide Industry Latest Market Share, Investment Trends, Growth, Size, Strategy
5. Predicting the fate of stem cells
6. Physical cues help mature cells revert into embryonic-like stem cells
7. Cleaner and greener cities with integrated transparent solar cells
8. Direct induction of chondrogenic cells from human dermal fibroblast culture by defined factors
9. Researchers discover and treat toxic effects of ALS mutation in neurons made from patients skin cells
10. Global Stem Cells Group, Inc. Announces Worldwide Alliance with EmCyte Corp. to Promote In-office Regenerative Medicine Solutions
11. Global Industry Analysts, Inc. Announces the Launch of a Major Research Program Analysing the Global Market for Circulating Tumor Cells and Cancer Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... -- The element of surprise has been a major advantage ... warning. Until now, epidemiologists had nothing to measure that ... in suboptimal responses to both the H1N1 pandemic of ... - http://photos.prnewswire.com/prnh/20141121/160242 That virus ... gene structural changes have been found that invariably to ...
(Date:11/21/2014)... TRU-D SmartUVC LLC and its UK partners, Rapid Disinfection ... TRU-D SmartUVC, at FIS 2014 in Harrogate, England ... Stand 23. The conference, hosted by Federation of ... largest infection-related event of its kind and brings together more ... events of its type throughout the world. This annual event ...
(Date:11/21/2014)... Los Angeles, CA (PRWEB) November 20, 2014 ... “A Short Walk to the Other Side” ... was an “Award-Winning Finalist in the “Fiction: Short Story” ... . , Jeffrey Keen, President and CEO of USA ... entries from mainstream and independent publishers, including Simon & ...
(Date:11/21/2014)... 20, 2014 The November 2014 issue ... an open access journal featuring the following articles:, ... to preserve photoresponsiveness in the retina , ... situ hybridization using chromogenic substrates in zebrafish , ... and protein electrophoresis , Nuclear LC3-positive puncta ...
Breaking Biology Technology:Viruses' Advantage of Surprise is Lost 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... The 14th Annual National Ergonomics,Conference and Exposition (NECE) ... a record number of conference sessions, and mark ... geared toward workplace design,and occupational health professionals, as ... environments. These new tracks are coupled with,the NECE,s ...
... AEterna Zentaris Inc.,(NASDAQ: AEZS , TSX: AEZ), ... oncology, today announced that its Senior Vice,President and ... a,company overview at the upcoming CIBC World Markets ... 2008 at 3:25 pm (eastern,time), at the Centre ...
... Shandong, China, Sept. 17 /Xinhua-PRNewswire-FirstCall/ --,China Biologic ... Biologic",or the "Company"), one of the leading ... China ("PRC"), today announced that the Company,received ... Drug Administration (the,"SFDA") to commence clinical trial ...
Cached Biology Technology:2008 National Ergonomics Conference Schedule Announced, Features Four New Tracks of Programming and Focus on Corporate Sustainability and Productivity; Most Product Debuts in Expo's 14-Year History 22008 National Ergonomics Conference Schedule Announced, Features Four New Tracks of Programming and Focus on Corporate Sustainability and Productivity; Most Product Debuts in Expo's 14-Year History 3China Biologic Receives SFDA Approval for Clinical Trial of Human Coagulation Factor VIII 2China Biologic Receives SFDA Approval for Clinical Trial of Human Coagulation Factor VIII 3
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
(Date:11/15/2014)... -- While we may still be a few years away from ... to gain instant access to all that ailed his patients, ... tablets for monitoring and measuring our health are cropping up ... a tad Orwellian to some, but a new survey suggests ... opportunities into their healthcare regime. These are some ...
(Date:11/7/2014)... Nov. 7, 2014  In conjunction with the ... Departments, The Community Foundation of the Verdugos has announced the ... JUSTICE PROJECT," a $250,000 initiative to keep the Verdugo Regional ... its first six months of existence, the Lab has processed ... for local law enforcement. "Because our number one ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
... London, New Delhi, Singapore and Washington DC (July 27, ... of Medical Decision Making , a large-scale, covert ... resources even with an extremely effective public health response, ... and initiating a response to it. The article ...
... 2009) An Italian research team, publishing in the ... is now available on-line without charge at http://www.ingentaconnect.com/content/cog/ct ... placenta may ultimately play a role in the treatment ... diseases caused by tuberculosis, chemical exposure, radiation or pathogens. ...
... Royal Holloway, University of London, has discovered evidence that ... frogs. The research, published in the August edition of ... about our long-tongued friends: wild frogs in the UK ... conducted her research with colleagues from the Institute of ...
Cached Biology News:Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making 2Placenta-derived stem cells may help sufferers of lung diseases 2Disease threat may change how frogs mate 2