Navigation Links
Whole sequence variation map reveals insight into evolutionary studies of rhesus macaque
Date:7/21/2011

July 20, 2011 BGI (previously known as the Beijing Genomics Institute), the largest genomics organization in the world, and Kunming Institute of Zoology, Chinese Academy of Sciences, together published the whole sequence variation map of rhesus macaque (Macaca mulatta) in Genome Biology on July 6th, 2011 (http://genomebiology.com/2011/12/7/R63). The study provides available resources for evolutionary and biomedical research.

Rhesus macaque, also called the Rhesus monkey, is one of the best known species of old world monkeys. Human and Rhesus macaque share a most recent common ancestor about 25 million years ago with 93.5% identify of their genome sequences. Due to its close relationship to human genetically and physiologically, rhesus macaque is the most extensively used non-human primate animals in biomedical research and animal models for human diseases research.

"Rhesus macaque is the second non-human primate to be sequenced in the world, which is a critical non-human primate animal model. The studies on genetic variations in rhesus macaque will pose an important significance to biomedical research." stated Xiaodong Fang, project principal of BGI and the co-lead author of the study.

With the advanced genome sequencing capability of BGI, researchers sequenced a Chinese rhesus macaque genome with 11.56-fold coverage. All sequenced reads were aligned to the reference Indian rhesus macaque genome (rheMac2) by using SOAP2, BGI's improved Short Oligonucleotide Alignment Program. There is 96% of the reference Indian macaque genome covered by at least one read. Compared with the sequenced reference Indian macaque genome, 5.5 million SNPs, including 2.56 million homozygous and 2.94 million heterozygous SNPs, were identified and 125,150 structural variations (SV) were detected. They also annotated 5,187 and 962 nonsynonymous SNPs to the macaque orthologs of human disease and drug-target genes, respectively.

"The variation map of rhesus macaque provides a useful framework for further genome-wide association studies and also has important applications to evolutionary and functional studies.

This study is only a part in our research on the genetics of rhesus macaque, and more detailed results will be published in the future." said professor Fang.

Researchers also established a genome-wide genetic variation database named the Chinese macaque single nucleotide polymorphism (CMSNP) database for data visualization. It can be accessed at http://monkey.genomics.org.cn.


'/>"/>

Contact: Lei Su
BGI-Marketing@genomics.cn
86-075-525-283-805
Beijing Genomics Institute
Source:Eurekalert

Related biology technology :

1. GenomeQuest to Lead Biomarker World Congress Panel on Applying Whole Genome Sequencing to Developing Companion Diagnostics
2. Researchers use X-ray diffraction microscope to reveal 3-D internal structure of whole cell
3. US Oncology Continues to Set the Standard as a VAWD(CM) Accredited Wholesale Distributor
4. The European HEALTHGRAIN consortium developed a definition for whole grain
5. Sanaria Inc. Receives Multi-Year U.S. NIH Phase II Small Business Innovation Research Grant to Develop a Genetically Attenuated Whole Parasite Malaria Vaccine
6. Stimulus Grant To Fund Whole-Genome Sequencing In Children With Autism
7. Rx100 Rescues Life if Administered Up to 72 Hours After Exposure to Lethal, Whole-Body Radiation!
8. CutisPharma, Inc. Receives Verified Accreditation for Wholesale Distributors from the National Association of Boards of Pharmacy for Woburn Facility
9. Box maker, Wildcat Wholesale, Makes Cryogenic Freezer Storage Boxes Affordable By Selling Directly To Labs
10. Sigma-Aldrich Introduces MISSION(R) LentiPlex(TM) Pooled shRNA Libraries to Enable Rapid Whole Genome Screening in Primary Cells, Stem Cells or Tumor Cells
11. BioNanomatrixs Revolutionary Whole Genome Analysis Platform Named to MIT Technology Reviews Annual 10 Emerging Technologies List
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... Alto, CA, USA (PRWEB) , ... October 11, 2017 , ... ... set to take place on 7th and 8th June 2018 in San Francisco, CA. ... policy influencers as well as several distinguished CEOs, board directors and government officials from ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased ... of over 5.5 million people each year. Especially those living in larger cities are ... - based in one of the most pollution-affected countries globally - decided to take ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
Breaking Biology Technology:
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities ... (physiological and behavioral), by technology (fingerprint, AFIS, iris recognition, ... recognition, and others), by end use industry (government and ... immigration, financial and banking, and others), and by region ... , Asia Pacific , and ...
Breaking Biology News(10 mins):