Navigation Links
Whole Genome Sequencing of Triple Negative Breast Cancer Reveals Previously Unreported Mutations
Date:12/6/2012

CARLSBAD, Calif., Dec. 6, 2012 /PRNewswire/ -- Whole genome sequencing has revealed previously unreported mutations in metastatic triple-negative breast cancer (TNBC), according to a study published by the journal Molecular Cancer Therapeutics.

The study, "Genome and transcriptome sequencing in prospective triple negative breast cancer uncovers therapeutic vulnerabilities," was sponsored by the Translational Genomics Research Institute (TGen) and US Oncology Research with support from Life Technologies Corporation (NASDAQ: LIFE) and is currently available online.

"The study underscores the potential clinical utility of genomic sequencing to improve cancer care," said Paul Billings, M.D., Ph.D., chief medical officer at Life Technologies. "Our hope is that in the not too distant future, sequencing will become available to many more patients and physicians."

In a sample of 14 tumors from ethnically diverse metastatic TNBC patients, the researchers found significant mutations and other changes in more than a dozen genes through whole-genome sequencing performed on Life Technologies' Applied Biosystems SOLiD™ 4.0 platform. The most frequently mutated gene among the tumors (seven of 14) was the TP53 tumor suppressor, and aberrations were observed in additional tumor suppressor genes including CTNNA1, which was detected in two of six African-American patients (who typically have more aggressive and treatment-resistant disease). Alterations were also seen in the ERBB4 gene, known to be involved in mammary-gland maturation during pregnancy and lactation, but not previously linked to metastatic TNBC.

The study included an "outlier analysis," which assessed expression patterns for each tumor when compared against the other tumor
'/>"/>

SOURCE Life Technologies Corporation
Copyright©2012 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related biology technology :

1. Hamamatsu Corporation Announces Exclusive Distribution of Its NanoZoomer Whole-Slide Scanners
2. Rubicon Genomics and Agendia Sign Agreement for Use of TransPLEX® Whole Genome RNA Amplification Technology With Symphony™ Cancer Diagnostics
3. Pig genome offers insights into the feistiest of farm animals
4. Researchers unlock disease information hidden in genomes control circuitry
5. In massive genome analysis ENCODE data suggests gene redefinition
6. Millions of DNA switches that power human genomes operating system are discovered
7. Human Genome Decoder and Artificial Life Creator, J. Craig Venter to Speak at "The Atlantic Meets the Pacific"
8. GenScript to Synthesize Yeast Genome with Johns Hopkins Scientists
9. Little known pregnancy disease, Hyperemesis Gravidarum, receives awareness with a $20,000 donation from the H.E.R. Foundation to begin Genome Research at UCLA
10. Two Blades Foundation licenses genome engineering technology to KWS
11. The Human Genome Is Displayed in the Dimension of Time in Web-Based Exhibition by Yonder Biology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... LAGUNA HILLS, Calif. , May 23, 2013 /PRNewswire-USNewswire/ ... CA recently became the first hospital on ... site robotic technology. This new surgical option provides women ... Marc Winter , ... gynecologist and surgeon and medical director of minimally ...
(Date:5/23/2013)... May 23, 2013 Northwest Biotherapeutics (NASDAQ: ... DCVax ® personalized immune therapies for solid tumor ... at this year,s American Society Of Clinical Oncology (ASCO) ... its leadership role in immune therapy.  (Logo: ... meeting is the pre-eminent conference focused on clinical treatment ...
(Date:5/23/2013)... BUSAN, South Korea , May 23, 2013 ... collaboration with SillaJen, Inc., a private biotherapeutics and ... of targeted biological products for cancer, announced today ... antibodies in patients treated with the oncolytic and ... This research was published in the ...
(Date:5/23/2013)... May 23, 2013 Watlow®, an ... complete thermal systems, recently introduced its new catalog, ... of experience in designing and manufacturing industrial heaters, ... products to serve diverse customer needs. , A ... at the beginning of the book. These options ...
Breaking Biology Technology:Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 2Pusan National University Announces Science Translational Medicine Publication Highlighting Landmark Demonstration of Functional Anti-Cancer Antibody Induction in Patients Following JX-594 Treatment 3Watlow Introduces Its New Industrial Heater Catalog 2
... - Judy Faulkner, founder and CEO of Epic Systems ... meeting held at the Promega BTC Center. The audience heard ... this unique, and successful company. , ,For over twenty years, ... events. She does not participate on outside company boards or ...
... this column Chicago or Minneapolis, because last week found me ... Corridor. It was a reminder that better days lie ahead ... innovative spirit and investment capital four of the Is ... system that binds Chicago, Milwaukee, the Rockford-Beloit-Janesville area, Madison, the ...
... helped Cisco Systems - the company that ... in the late '80s ad early '90s. But subsequent ... from careful expansion of the company's product line. Morgridge ... Business Leaders Forum Breakfast. , ,Morgridge joined ...
Cached Biology Technology:Epic's Founder Judy Faulkner Speaks on Culture, Business Beliefs, and Recruiting: WTN Exclusive Coverage 2Epic's Founder Judy Faulkner Speaks on Culture, Business Beliefs, and Recruiting: WTN Exclusive Coverage 3Traveling the I-Q Corridor: Upper Midwest technology future is bright 2Traveling the I-Q Corridor: Upper Midwest technology future is bright 3Cisco Chairman Praises University Research 2Cisco Chairman Praises University Research 3
(Date:5/24/2013)... noise in one French Quarter neighborhood of New Orleans ... ordinances, Annette Hurley, PhD, Assistant Professor of Audiology at ... a third-year LSUHSC doctor of audiology student, recommend that ... health. Their case study is published online in the ... ., "An important part of an audiologist,s practice is ...
(Date:5/24/2013)... scientists have focused among other factors on drugs ... is the accumulation of A-beta that causes the known plaques ... formation of A-beta is APP. Alessia Soldano and Bassem Hassan ... APPL the fruit-fly version of APP in the ... Leuven): "We have discovered that APPL ensures that brain cells ...
(Date:5/24/2013)... conference of 500 leading water scientists from around the ... reforms, "in the short span of one or two ... Earth will be living under the handicap of severe ... for which there is no substitute. This handicap will ... The scientists bluntly pointed to chronic underlying problems led ...
Breaking Biology News(10 mins):Please do try this at home 2A new strategy required in the search for Alzheimer's drugs? 2A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 2A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 3A majority on Earth face severe self-inflicted water woes within 2 generations: Scientists 4
... your eyes from the leading cause of blindness in western ... the aid of a new eye instrument, they have launched ... with his super-human strength could also explain why the 77-year-old ... other vegetables like sweetcorn, kale and broccoli are rich in ...
... of India constitute more than one-sixth of the ... studies related to genetic diseases. And with the ... urban and western lifestyles have risen to near-epidemic ... particular importance. , In response to this ...
... an unusual strategy for infecting cornea cells that may also explain ... researchers at the University of Illinois at Chicago College of Medicine. ... the Journal of Cell Biology. , Both strains of the ... the mouth, and HSV-2, genital herpes -- can infect the cornea, ...
Cached Biology News:Why Popeye only has eyes for spinach 2Researchers make progress in studying genetic traits of India-born populations 2Study shows how herpes infects cornea, evades immune cells 2