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White House Highlights Innovative Arthritis Research
Date:6/20/2013

-TNF therapy, and the PGRN is supporting the genotyping of these samples for the Challenge itself.

"The Consortium of Rheumatology Researchers of North America (CORRONA) is very pleased to contribute the validation cohort of rheumatoid arthritis patient samples who were prescribed anti-TNF biologic drugs," said Jeff Greenberg, MD, MPH, Chief Scientific Officer of CORRONA.  "The challenges of pharmacogenetic research and personalized medicine for rheumatoid arthritis patients require innovative and highly collaborative research teams to improve patient outcomes."

The Challenge will open this fall and complete in the winter of 2014. The first phase of the challenge is a discovery phase in which teams use the data to build genetic predictors of response to anti-TNF therapy. The second phase is a validation assessment in which challenge participants' predictive models will be tested against a newly generated rheumatoid arthritis dataset (from CORRONA). The team with the most highly predictive model in the validation assessment will be deemed the "winner."  The results of the challenge will be published in a highlighted article as a collaborative effort with Nature Genetics.  The winning classifier will potentially be used to drive a prospective clinical trial with materials and data collected through the Arthritis Internet Registry.

"Sage Bionetworks/DREAM are delighted to be in lockstep on this challenge with the Arthritis Foundation," said President of Sage Bionetworks, Dr. Stephen Friend.  "Their support for a prospective clinical trial to evaluate the winning model highlights the Arthritis Foundation's leading role in the development of impactful, precision medicine approaches to health."

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SOURCE Arthritis Foundation
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