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White House Highlights Innovative Arthritis Research
Date:6/20/2013

field by organizing multiple groups to attack the same problems from different angles. Earlier this year, DREAM and Sage Bionetworks merged their efforts to work on future DREAM Challenges together and take them to a new level of operation and impact.

"The Rheumatoid Arthritis Responder Challenge represents a unique interaction among an international team of researchers from academics and industry who share a common goal: improve the lives of patients with a debilitating form of arthritis," said Director of Genetics & Genomics at Brigham & Women's Hospital, Dr. Robert Plenge. "We will make complex genetic and genomic datasets available to researchers from across the world through a unique computing platform developed by Sage Bionetworks.  By leveraging the power of the crowd, we hope to solve a vexing clinical problem about predicting which patients will respond to an expensive and potentially dangerous medication, anti-TNF therapy."

A unique component of the Rheumatoid Arthritis Responder Challenge is the diversity of participation across a number of groups from academic institutions, private foundations and for-profit companies.  The funding and support to carry out the Challenge and to support Sage Bionetworks' cloud-based data analysis platform (Synapse) where the Challenge will take place, derives from the Arthritis Foundation and several major pharmaceutical companies.  Additional support for the Challenge comes from data and samples contributed by the Consortium of Rheumatology Researchers of North America, Inc. (CORRONA), the National Institutes of Health Pharmacogenomics Research Network (PGRN), the Broad Institute, and academic researchers from across the world.  For example, CORRONA is providing unique clinical samples from a prospective study of rheumatoid arthritis patients treated with anti
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SOURCE Arthritis Foundation
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