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When to Wait and When to Treat? New Program Will Search for Biomarkers in Men With Prostate Cancer to Help Find an Answer

SEATTLE, May 2 /PRNewswire/ -- Researchers at Fred Hutchinson Cancer Research Center have a lead role in a new public/private partnership to create the first systematic surveillance program of men with prostate cancer to look for biological clues to help determine when to wait and when to treat the disease. The project was announced by the Canary Foundation and the National Cancer Institute.

Peter Nelson, M.D., of the Hutchinson Center's Clinical Research and Human Biology divisions, will lead the Canary Prostate Consortium. This group of six institutions nationwide will enroll men in a cancer-surveillance study to look for biomarkers -- proteins in the blood that could predict prostate-tumor aggressiveness.

The new study is meant to help answer a key question that has vexed physicians and researchers: When is it best to treat prostate cancer versus observation or "watchful waiting." For most men with prostate cancer, the disease never progresses to become a serious health problem, yet most receive some sort of treatment, such as radiation or surgery. Such treatments can have side effects, such as impotence and incontinence, which can be worse than the low-grade cancer. Currently it is challenging to accurately predict when inactive or slow-growing prostate tumors will become aggressive.

"There's an emerging consensus that we dramatically over treat prostate cancer in general," said Nelson. "The overall prevalence of the disease in the population far exceeds the number of men whose disease progresses to cause serious problems. Yet, there are clearly many prostate cancers that behave aggressively and patients benefit from treatment. It is a challenging problem."

In the study, men diagnosed with early-stage prostate cancer will not be treated right away but will be closely followed in an active surveillance program involving regular collection of blood and urine samples as well as prostate biopsies. A new repository for blood and DNA samples will be located at the Hutchinson Center. The repository will be funded by the Canary Foundation. NCI's Early Detection Research Network (EDRN), the federal agency that is partnering with the Canary Foundation, will establish disease-specific Common Data Elements, a biospecimen management system and a protocol oversight program. The EDRN data management and coordinating center is based at the Hutchinson Center under the direction of Zideng Feng, Ph.D., a member of the Hutchinson Center's Public Health Sciences Division.

The samples will be tested for candidate biomarkers -- proteins in the blood -- that can signal when indolent disease has progressed to more aggressive illness. Such biomarkers could help physicians better determine when to initiate treatment versus watchful waiting.

Each of the study institutions also has a "retrospective" tissue collection of samples taken from unrelated studies. These will also be examined to ascertain the accuracy of predictive biomarkers.

"We are proud to launch this new study with EDRN and with the participation of leading research institutes," said Nelson, who is also a professor of oncology at the University of Washington School of Medicine. "Through collaboration we can make bigger strides in providing better, more individualized treatment for prostate-cancer patients."

The Canary Foundation is providing initial funding for the Prostate Active Surveillance Study. The five institutions that will enroll patients are University of Washington, Stanford University, University of California at San Francisco, University of British Columbia and University of Texas Health Science Center in San Antonio.

About Fred Hutchinson Cancer Research Center

At Fred Hutchinson Cancer Research Center, interdisciplinary teams of world-renowned scientists and humanitarians work together to prevent, diagnose and treat cancer, HIV/AIDS and other diseases. Our researchers, including three Nobel laureates, bring a relentless pursuit and passion for health, knowledge and hope to their work and to the world. For more information, please visit

About Canary Foundation

Named after the "early detection" role canaries once played by alerting coal miners of hazardous fumes, Canary Foundation is the nation's only nonprofit organization devoted exclusively to the early detection of cancer. While almost $10 billion is spent annually on cancer research in the United States, the vast majority is allocated to developing new cancer treatments and caring for patients. Surprisingly, little funding is available to researchers investigating new ways to detect cancer at its earliest, curable stages. Specifically, Canary Foundation is supporting researchers working towards identifying cancer early through a simple blood test and then isolating it with imaging. All administrative and overhead costs are underwritten by operating grants, allowing 100 percent of contributions to go to early detection research activities. For more information about the Canary Foundation and its programs, please visit

About the NCI Early Detection Research Network

The Early Detection Research Network (EDRN), an initiative of the National Cancer Institute (NCI), brings together dozens of institutions to help accelerate the translation of biomarker information into clinical applications and to evaluate new ways of testing cancer in its earliest stages and for cancer risk.


Dean Forbes

(206) 667-2896

SOURCE Fred Hutchinson Cancer Research Center
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