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When proteins, antibodies and other biological molecules kiss, a new kind of biosensor can tell
Date:9/20/2007

at cover the surface of the proteins: When two proteins react they squeeze the water molecules out of the area where they bind together. This displacement changes the density of the liquid slightly which, in turn, alters its index of refraction.

BSI has some potential cost advantages compared to current techniques. The price of the equipment required for BSI is modest and the entire system could easily be miniaturized and integrated with lab on a chip systems, says Bornhop. It is also easy to adapt for high-throughput operation: processing hundreds or thousands of different samples at the same time, he says.

Vanderbilt has applied for and received two patents on the process and has several other patents pending. The university has issued an exclusive license to develop the technology to Molecular Sensing, Inc. Bornhop is one of the founders of the start-up and serves as its chief scientist. The company plans on completing a prototype system this fall.


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Contact: David F. Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert

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Antibodies were affinity purified using epitopes specific to QKI immobilized on solid support....
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