Navigation Links
Week-24 Interim Results From Phase 2b PILLAR Study to be Presented as Late-Breaker at AASLD
Date:10/30/2010

BOSTON, Oct. 30 /PRNewswire/ -- Tibotec Pharmaceuticals (Tibotec) announced today the company will present the results of a Week-24 planned interim analysis of the phase 2 response-guided PILLAR study in treatment-naive patients with chronic genotype 1 hepatitis C virus (HCV) at the 61st Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston, MA., USA. The data will be presented as part of a late-breaker oral presentation on Monday, November 1.  

The results showed that in the four TMC435 treatment groups between 79 and 86 percent of patients were able to stop all therapy at Week-24, according to the response criteria defined in the study protocol. There were no relevant differences for adverse events between TMC435 treatment groups and placebo. TMC435, a hepatitis C protease inhibitor, dosed once daily (q.d.) is being developed jointly by Tibotec Pharmaceuticals and Medivir.

The PILLAR study [Protease Inhibitor TMC435 trial assessing the optimaL dose and duration as once daiLy Anti-viral Regimen] (TMC435-C205; NCT00882908) is an ongoing, five-arm, global phase 2b randomized, double-blind, placebo controlled study in 386 treatment-naive patients. TMC435 was administered in doses of 75mg or 150mg q.d. for either 12 weeks or 24 weeks in combination with 24 weeks of peg-interferon and ribavirin (PR). Patients in the placebo arm receive 24 weeks of placebo plus peg-interferon and ribavirin followed by 24 additional weeks of peg-interferon and ribavirin treatment. The primary endpoint of the study is sustained virologic response at Week-72 (SVR24). The PILLAR study is being conducted in 13 countries in Europe, North America, and Australasia.

Patients receiving TMC435 were allowed to stop all treatment at week 24 when a) HCV RNA levels < 25 IU/mL at week 4  and b) HCV RNA < 25 IU/mL levels at weeks 12, 16 and 20. Patients who did not meet the above resp
'/>"/>

SOURCE Tibotec Pharmaceuticals
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Chromos obtains interim order in connection with arrangement, announces annual and special meeting of shareholders and confirms mailing of information circular
2. BioMS Medical announces positive interim analysis on phase III trial of dirucotide (MBP8298) for multiple sclerosis
3. Fufeng Announces 2008 Interim Results With Strong Sign of Recovery
4. LPBP Inc. - Re-filing certification of interim filings
5. Bavarian Nordic A/S - Interim Report for the Period 1 January to 30 June 2008
6. Arpida Reports Interim Results for Six Months to 30 June 2008
7. Exiqon A/S: Interim Report for the Period 1 January - 30 June 2008 (Unaudited)
8. Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure
9. Misonix Announces Interim Distribution Agreement for Italy
10. Oncolytics Biotech Inc. Investigators Present Interim U.S. REOLYSIN(R) Phase II Sarcoma Trial Data
11. Interim Analysis of Data from e-HEALING Registry of OrbusNeichs Genous(TM) Bio-engineered R stent(TM) to be Presented at AHA Scientific Sessions 2008
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced results for ... complete 2014 second quarter financial statements and MD&A have been filed on ... 30, , Six-months ended June 30, ( in CDN$,000 except ... , 2014 , 2013 Revenue , 2,459 ... profit , 56 , 1,485 , 385 ...
(Date:8/22/2014)... investigated for application as catalysts, sensors, drug ... in photonics and molecular electronics. Gaining knowledge ... physical and chemical properties, has been challenging. ... demonstrated that high-resolution electron microscopy can be ... which all gold atoms are observed. The ...
(Date:8/22/2014)... Research and Markets has announced ... Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) ... offering. The global molecular biology enzymes ... is expected to grow at a CAGR of 13.74% ... kits, & reagents find applications in a large number ...
(Date:8/22/2014)... SC (PRWEB) August 22, 2014 ... indisputable acknowledgement is a national disgrace. Furthermore, every ... in establishing the current, deplorable state of unorganized ... "5 great mistakes," to merely serve as a ... the extent of colossal failure(s) that have accumulated ...
Breaking Biology Technology:Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 2Global Molecular Biology Enzymes, Kits, & Reagents (Cloning, Epigenetics, PCR, Restriction Digestion, Sequencing) Market - Forecast to 2018 35 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2
... pleasant June day in Fitchburg, Secretary of Commerce Cory Nettles ... His logic? Invest in Wisconsins economy as you would ... some intermediate growers, and a few bucks to riskier ventures. ... Before making a single dollar of investment, Wisconsin must ...
... a Doctorate in Acronyms to figure out what's happening these ... short course in how to read the alphabet soup of ... to your home or business: , , SBC: ... percent of the state's combined residential and business lines. Once ...
... we have all heard a lot about generic drugs lately. ... of people without medical insurance in the U.S. and perhaps even ... the market to help cap some of the rising costs of ... it is estimated that 41.2 million Americans or 14.6 percent of ...
Cached Biology Technology:GYA: Grow Your Assets 2The ABC's of telephone regulation in Wisconsin 2The ABC's of telephone regulation in Wisconsin 3The Generic Drug Industry in Illinois 2The Generic Drug Industry in Illinois 3The Generic Drug Industry in Illinois 4
(Date:8/21/2014)... American singles found that during sex with a ... On average, men experience orgasm 85.1 percent of ... difference. For women, however, orgasm occurrence is less ... of the time during sex with a familiar ... sexual orientation, with lesbian women experiencing orgasm more ...
(Date:8/21/2014)... they are the ultimate source of all organic matter ... on algae, too, to suck up climate-warming carbon dioxide ... of the ocean. Now, by using a combination of ... that viruses infecting those algae are driving the life-and-death ... stays essentially the same, and this has important implications ...
(Date:8/21/2014)... the food intake, health and quality of life of ... projects at the University of Waterloo receiving close to ... Health Research (CIHR). , Professor Heather Keller, of ... a Schlegel research chair in nutrition and aging, will ... Canadians living in long-term care homes are poorly nourished. ...
Breaking Biology News(10 mins):Orgasm rates for single women less predictable than men's, vary by sexual orientation 2Orgasm rates for single women less predictable than men's, vary by sexual orientation 3Orgasm rates for single women less predictable than men's, vary by sexual orientation 4Viruses take down massive algal blooms, with big implications for climate 2Grants will fund landmark aging research at Waterloo 2
... Carolina State University have developed a more efficient ... significantly reduces the waste that results from conventional ... step toward creating a commercially viable new source ... more efficient and less expensive," says Dr. Ratna ...
... are reporting dramatic new real-world evidence supporting the idea ... disease. It appears in a new study showing a ... of stored drinking water, and health in households in ... ACS, Environmental Science & Technology , a semi-monthly ...
... Sweet news for those looking for new antibiotics: A ... the FASEB Journal ( http://www.fasebj.org ) explains for ... shows that bees make a protein that they add to ... to treat burns and skin infections and to develop new ...
Cached Biology News:New technique improves efficiency of biofuel production 2Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria 2
... for proteomic scale kinase profiling, quantitative measurement ... research built on the flexible and powerful ... are available as part of our comprehensive ... Probe Content Our standard ...
... integrated informatics solution for the research ... response modeling. This web-based software comes ... base of biological networks, and can ... of extracting pathway-related information from scientific ...
... its amino acid acceptor activity using aminoacyl-tRNA synthetase ... Gly, Ile, Lys, Pro, Thr, Val, Arg, Glu, ... One unit will yield an A 260 ... cm light path). Physical Form: lyophilized ...
... Dithiothreitol DTT White solid.. PACKAGED ... to thiols, so reaction is "driven" to completion. ... contain waxy surfactant found in many other preparations. ... Purity: ≥97% by titration. Contaminants: ...
Biology Products: