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Webcast Alert: Isis Pharmaceuticals Announces its Analyst & Investor Day
Date:11/9/2007

CARLSBAD, Calif., Nov. 9 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announces the following webcast:

What: Isis' Analyst & Investor Day

When: Tuesday, November 13, 2007, at 9:00 a.m. ET / 6:00 a.m. PT

Where: http://www.isispharm.com

How: Live on the Internet. Simply log onto our web site listed

above.

Contacts: Kristina Lemonidis

Associate Director, Investor Relations

(760) 603-2490

Amy Blackley, Ph.D.

Manager, Corporate Communications

(760) 603-2772

If you are unable to participate during the live event, a replay of the webcast will be available for a limited time at http://www.isispharm.com.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 18 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing drugs for a wide variety of diseases. Ibis Biosciences, Inc., Isis' wholly owned subsidiary, is developing and commercializing the Ibis T5000(TM) Biosensor System, a revolutionary system to identify infectious organisms. Isis is a joint owner of Regulus Therapeutics LLC, a joint venture focused on the discovery, development and commercialization of microRNA therapeutics. As an innovator in RNA-based drug discovery and development, Isis is the
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SOURCE Isis Pharmaceuticals, Inc.
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