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Web-crawling the brain
Date:3/9/2011

BOSTON, Mass. (March 9, 2011) The brain is a black box. A complex circuitry of neurons fires information through channels, much like the inner workings of a computer chip. But while computer processors are regimented with the deft economy of an assembly line, neural circuits are impenetrable masses. Think tumbleweed.

Researchers in Harvard Medical School's Department of Neurobiology have developed a technique for unraveling these masses. Through a combination of microscopy platforms, researchers can crawl through the individual connections composing a neural network, much as Google crawls Web links.

"The questions that such a technique enables us to address are too numerous even to list," said Clay Reid, HMS professor of neurobiology and senior author on a paper reporting the findings in the March 10 edition of Nature.

The cerebral cortex is arguably the most important part of the mammalian brain. It processes sensory input, reasoning and, some say, even free will. For the past century, researchers have understood the broad outline of cerebral cortex anatomy. In the past decade, imaging technologies have allowed us to see neurons at work within a cortical circuit, to watch the brain process information.

But while these platforms can show us what a circuit does, they don't show us how it operates.

For many years, Reid's lab has been studying the cerebral cortex, adapting ways to hone the detail with which we can view the brain at work. Recently they and others have succeeded in isolating the activities of individual neurons, watching them fire in response to external stimuli.

The ultimate prize, however, would be to get inside a single cortical circuit and probe the architecture of its wiring.

Just one of these circuits, however, contains between 10,000 and 100,000 neurons, each of which makes about 10,000 interconnections, totaling upwards of 1 billion connectionsall within a single cir
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Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

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