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Waters Unveils Industry's First Integrated LC/MS Platform for Proteins, Peptides, and Glycans Analysis at WCBP 2013
Date:1/28/2013

alysis, peptide mapping and supporting general bio-separations. Today, Waters extended the solution's reach to support a mix of quadrupole time-of-flight (Q-Tof) MS and optical detection instruments within a networked laboratory workgroup. The ability to deploy UNIFI-based systems within regulated or non-regulated laboratory environments provides biopharmaceutical companies the flexibility to employ high resolution UPLC bioseparations and high performance mass analysis across the entirety of their development and quality organizations.

The newly introduced released Glycan application workflow expands the platform's capabilities to support routine assignment and profiling of released glycans using fluorescence detection. The combination of high performance UPLC HILIC (hydrophilic interaction chromatography) separations, Waters' calibration standards and reagents, and access to the NIBRT/Waters GlycoBase 3+ UPLC glycan unit reference database enables confident glycan assignments, quantification, and profiling.

Developed by Professor Pauline Rudd's research team at Ireland's National Institute for Bioprocessing Research and Training (NIBRT), the GlycoBase 3+ Database is the first-of-its-kind repository of glycan chromatographic retention data, expressed in glucose calibration units, and encompassing the diverse sets of glycan structures associated with modern biotherapeutic glycoproteins.

The Biopharmaceutical Platform Solution with UNIFI now features:

  • ACQUITY UPLC H-Class and the H-Class Bio System featuring a bio-inert flow path and quaternary solvent management with Auto-Blend Plus™ Technology, for flexibility in executing high-resolution bioseparations;
  • Waters Peptide, Protein, and G
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SOURCE Waters Corporation
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