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Waters Publishes Rapid and Specific Method of Detection for Melamine in Infant Formula and Liquid Milk, in Support of China's Ministry of Science and Technology
Date:10/17/2008

MILFORD, Mass., Oct. 17 /PRNewswire-FirstCall/ -- Waters Corporation (NYSE: WAT) today published a rapid method for the detection of melamine in infant formula and liquid milk as outlined by requirements of China's Ministry of Science and Technology (M.O.S.T.). The new method uses Waters(R) ACQUITY(R) TQD, liquid chromatography combined with tandem quadrupole mass spectrometry (UPLC/MS/MS) operated in Multiple Reaction Monitoring (MRM) mode, and Waters MassLynx(TM) 4.1 Software with IntelliStart(TM) technology for data acquisition and MS parameters optimization.

Following an increased incidence of kidney stones and renal failure in infants in China believed to be associated with the ingestion of contaminated infant formula, M.O.S.T. issued guidelines for the development of melamine detection methods to be used throughout the nation. Specifically, M.O.S.T. is seeking accurate, reproducible detection of melamine of less than or equal to 2 mg/kg (ppm). Moreover, authorities in the US have declared that no tolerance can be set for the presence of melamine in infant formula. This indicates the need for an analytical method capable of accurately quantifying melamine across a wide range of concentrations.

Waters published method meets or exceeds these requirements. Specifically, Waters UPLC/MS/MS detection method can detect melamine contamination as low as 1 microgram/Kg (ppb) with an achievable sample throughput better than one sample every 15 minutes.

"Waters has a history of working with China's Ministry of Science and Technology by listening to their needs and providing solutions," said James Willis, Senior Director, Chemical Analysis Business for the Waters Division. "Analytical instrument companies in China are all prov
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