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Waters Introduces Highest Performing UPLC Ever Engineered - the New ACQUITY UPLC I-Class

MILFORD, Mass., June 1, 2011 /PRNewswire/ -- Waters Corporation (NYSE: WAT) today introduced the new Waters® ACQUITY UPLC® I-Class System, the highest performing UPLC® system ever engineered taking UltraPerformance LC® separations technology to the next level.  For scientists challenged by the most difficult separations, the ACQUITY UPLC I-Class features the lowest system dispersion and lowest carryover in the industry today. Low dispersion maximizes peak capacity thereby advancing chromatographic separations and optimizing the performance of any mass spectrometer.

"The scientific discoveries with the biggest potential to improve our lives often rely on samples and compounds that are the most difficult to understand. The ACQUITY UPLC I-Class System was designed specifically for the rapid pace of laboratories on the cutting edge of research," said Art Caputo, President of the Waters Division. "Design and function of the I-Class are based on continuous customer input resulting in improvements in sub-two-micron separation that only the originator of the technology can exploit. Whether customers need to rapidly analyze sample-limited compounds amid a complex matrix or they seek to optimize the performance of any mass spectrometer on the market, ACQUITY UPLC I-Class enables scientists to solve their most complex separations and detection challenges."

Keeping pace with today's most advanced laboratories, the ACQUITY UPLC I-Class System excels when analyzing complex, sample-limited compounds.   Sample-limited compounds include high potency medications, trace levels of food or water contamination, and (advanced) sophisticated biotherapeutics.  These samples can represent complex separation challenges requiring an LC system that can maximize the benefits of sub-two-micron for faster throughput and optimized MS performance.

While there are many innovations built into the new ACQUITY UPLC I-Class, minimal system volume is a new key feature. Reduced system volume significantly decreases dispersion rates for reproducibly higher resolution and superior peak capacity. Reduced dispersion and small peak volumes extend the sensitivity of any mass spectrometer. Additionally, low dispersion footprint allows users to reduce their separation cycle times without impact to the separation as resolution is maintained even for ballistic gradients lasting less than one minute. Also importantly, new design and materials dramatically reduce sample carryover effects, thus increasing user confidence in results.

The ACQUITY UPLC I-Class also features class leading flexibility and precise sampling capabilities. Depending on application needs, users can choose either the highest precision and lowest dispersion fixed-loop Sample Manager, or the world's first low dispersion variable volume Sample Manager with a flow-through needle design, which delivers high-precision injections, excellent sample recovery, and lowest sample carryover optimizing the performance for even the most sensitive mass detectors.


Seven years ago, Waters pioneered a new category of chromatographic performance with the commercialization of sub-2 micron particle columns engineered in tandem with advanced instrumentation and fluidics modules to deliver superior performance at higher pressures through the introduction of UPLC technology.  The result has been significant improvements in analytical resolution and sensitivity while increasing analytical speed.

To date, Waters has installed thousands of ACQUITY UPLC Systems, supported nearly 900 peer-reviewed papers, demonstrated reduced solvent consumption up to 95 percent for greener laboratories, and has served the needs of regulatory agencies around the globe.

A growing family of application focused liquid chromatography systems, the ACQUITY UPLC I-Class system joins ACQUITY UPLC H-Class, ACQUITY UPLC H-Class Bio, nanoACQUITY UPLC®, ACQUITY UPLC Systems with 2D Technology, nanoACQUITY UPLC System with 2D Technology, nanoACQUITY UPLC System with HDX Technology, PATROL UPLC® Process Analyzer, PATROL UPLC Laboratory Analyzer, and UPLC with On-line SPE Technology.

Adoption of UPLC technology is accelerated through a diverse range of systems based on a common, proven platform. Benefits of this approach reach well beyond targeted or individual laboratories. They are at the heart of today's business, academic and regulatory needs, ensuring that scientific, operational, sustainability, and profitability goals are met.

For more information on the ACQUITY UPLC I-Class, please visit

About Waters Corporation (

For over 50 years, Waters Corporation (NYSE: WAT) has created business advantages for laboratory-dependent organizations by delivering practical and sustainable innovation to enable significant advancements in such areas as healthcare delivery, environmental management, food safety, and water quality worldwide.

Pioneering a connected portfolio of separations science, laboratory information management, mass spectrometry and thermal analysis, Waters technology breakthroughs and laboratory solutions provide an enduring platform for customer success.

With revenue of $1.64 billion in 2010 and 5,400 employees, Waters is driving scientific discovery and operational excellence for customers worldwide.

Waters, ACQUITY, UltraPerformance Liquid Chromatography, nanoACQUITY, PATROL, and UPLC, are trademarks of Waters Corporation.

SOURCE Waters Corporation
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