Navigation Links
Visualizing asthma-causing immune cells at work
Date:11/6/2008

Immune cells known as eosinophils have a central role in causing asthma. Now, a team of researchers at Massachusetts General Hospital, Boston, has developed approaches to noninvasively visualize in real-time eosinophil responses in the lungs and airways of mice with a disease that mimics asthma (experimental allergic airway inflammation); they hope that these approaches might be developed to help assess the efficacy of treatments (both old and new) for the disease.

The team, led by Mikael Pittet and Ralph Weissleder, visualized eosinophils at single-cell resolution using various noninvasive real-time molecular imaging technologies (specifically, near-infrared fluorescence fiber optic bronchoscopy, intravital microscopy, and fluorescence-mediated tomography) following injection of an optical sensor that targets proteins produced by eosinophils known as MMPs. Using a combination of the sensitive optical sensor and fluorescence-mediated tomography, it was observed that dexamethasone (a drug used to treat severe asthma) decreased the number of eosinophils in the lungs of mice with allergic airway inflammation. As some of the imaging techniques have the potential to be developed for the clinic, the authors suggest that in combination with an appropriate optical sensor they might improve our ability to diagnose asthma and assess treatment efficacy.


'/>"/>

Contact: Karen Honey
press_releases@the-jci.org
215-573-1850
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. ImmuneRegen BioSciences Files 8-K that Highlights Enclosed Shareholder Letter Discussing Recent Achievements and Outlook
2. ImmuneRegen Responds to Defense Threat Reduction Agency Request for Information
3. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
4. MedImmune Celebrates Opening of New Pilot Lab at Gaithersburg Headquarters
5. Sanofi Pasteurs Investigational H5N1 Influenza Vaccine Achieves High Immune Response at low Dosage
6. ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles
7. Advanced Immune Support Formula Licensed From UC Berkeley Launched
8. MedImmune Recognized by Local Volunteer Organization for Its Employees Exceptional Commitment to Community Service within Montgomery County
9. MedImmune to Present RSV Surveillance and Cost-Effectiveness Data at American Academy of Pediatrics National Conference & Exhibition
10. AstraZeneca Bolsters Its Worldwide Biologics Division Through Integration of Cambridge Antibody Technology Into MedImmune
11. MedImmune Announces Seven Key Promotions and New Hires
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... -- Neogen Corporation (Nasdaq: NEOG ) announced today ... 2015 fiscal year, which ended Aug. 31, was $8,883,000 ... $7,839,000 in the first quarter of last year. Adjusted ... earnings per share in the current quarter were $0.24, ... quarter revenues increased 15% to $67,599,000, from the previous ...
(Date:9/22/2014)... METTLER TOLEDO is pleased to ... device CNS110 ScanTape™ . Replacing a traditional ... greater ease and accuracy for transport and logistics ... enhance productivity—an important benefit for load planning and ... profits. , Usable at any point in ...
(Date:9/21/2014)... scientists have discovered how to produce ultra-thin "diamond nanothreads" ... than that of today,s strongest nanotubes and polymers. A ... by John V. Badding, a professor of chemistry at ... September 2014 issue of the journal Nature Materials ... discovery is intriguing because the threads we formed have ...
(Date:9/20/2014)... MediVet America and NanoFiber ... surgery at the specialized Wolvega Horse Clinic. , Due ... tendon was ruptured 90% and her deep digital flexor ... death sentence for a horse. , The clinic has ... . This revolutionary regenerative option for ruptured tendons ...
Breaking Biology Technology:Neogen reports 13% net income increase 2Neogen reports 13% net income increase 3Neogen reports 13% net income increase 4Neogen reports 13% net income increase 5Neogen reports 13% net income increase 6Neogen reports 13% net income increase 7ScanTape™ Handheld Dimensioner Increases Processing Volume 2Smallest possible diamonds form ultra-thin nanothreads 2Smallest possible diamonds form ultra-thin nanothreads 3Smallest possible diamonds form ultra-thin nanothreads 4World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3
... to fuel requires several steps: chemical pretreatment to break ... to remove the toxic chemicals required in pretreatment, and ... Virginia Tech researchers have discovered an enzyme mixture that ... biomass (hydrolysate), meaning that the detoxification step is unnecessary, ...
... 2011 Cadence Pharmaceuticals, Inc. (Nasdaq: ... commercializing proprietary product candidates principally for use in the hospital ... and full year ended December 31, 2010 financial results on ... host a conference call and live webcast to discuss the ...
... Bulletin Board: GOVX ), an Atlanta-based biotechnology company ... its financial results for the fourth quarter and year ended ... of $478,784 for the fourth quarter ended December 31, 2010, ... comparable period in 2009. For the full year of 2010, ...
Cached Biology Technology:Enzyme cocktail could eliminate a step in biofuel process 2GeoVax Labs Reports Fourth Quarter and Year-End 2010 Financial Results 2GeoVax Labs Reports Fourth Quarter and Year-End 2010 Financial Results 3GeoVax Labs Reports Fourth Quarter and Year-End 2010 Financial Results 4GeoVax Labs Reports Fourth Quarter and Year-End 2010 Financial Results 5GeoVax Labs Reports Fourth Quarter and Year-End 2010 Financial Results 6
(Date:9/19/2014)... researchers from several Harvard University labs in collaboration ... aspiring researchers with the intellectual raw materials needed ... soft, flexible materials. , With the advent of ... in manufacturing technology, soft robotics is emerging as ... conventional rigid robot design, but working with pliable ...
(Date:9/19/2014)... biology professor will study multifunctional and specialized spinal ... a National Science Foundation grant in the amount ... Berkowitz, professor in the Department of Biology, OU ... the differences between the multifunctional and specialized spinal ... use and what connections they make. Berkowitz ...
(Date:9/19/2014)... which over thousands of years has adapted to the arctic ... makes the cold dangerous for you. , This is happening ... the cold provoking substance, called nonylphenol, comes from the use ... of being a endocrine disruptor, but when entering the worm ... to protect the cells in its body from cold damage. ...
Breaking Biology News(10 mins):Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... aging and many age-related diseases is oxidative stress," says the ... of pathology. The skin of a bitten apple will brown ... that is a good metaphor for the damage that oxidative ... over time. , Humans and other organisms depend on oxygen ...
... Avoiding quicksand along the banks of the Ivindo River in ... patterns of electricity created by fish in the water. ... groups of local electric fish have different DNA, different communication ... have found a case where two types of electric signals ...
... Using a "clot buster" drug normally reserved for treating patients ... double the number of patients who could be revived from ... more than 260,000 people a year nationwide ?and at least ... as a new therapy for this abrupt and catastrophic loss ...
Cached Biology News:Free radical cell death switch identified 2Electric fish in Africa could be example of evolution in action 2Clot-busting drug helps revive cardiac arrest patients 2
Umbilical cord blood CD14+ Monocytes, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood basophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Umbilical cord blood CD19+ B cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Monocytes, B Cells and NK Cells...
Human peripheral blood neutrophils, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Granulocytes...
Biology Products: