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VisionGate Closes $2 Million Financing and Announces Collaboration to Evaluate Its 3D Cell Imaging Platform for Early Lung Cancer Detection
Date:10/19/2011

PHOENIX, Oct. 19, 2011 /PRNewswire/ -- VisionGate, Inc., a company developing a revolutionary non-invasive test for the early detection of lung cancer, today reported that it has raised approximately $2 million in the first tranche of a financing round.  The company also announced that it has entered into a collaboration with the Sheba Medical Center in Israel to evaluate whether VisionGate's LuCED™ test can reduce false positive results when used in conjunction with x-ray computed tomography (CT) screening for early lung cancer.

LuCED is used in tandem with VisionGate's automated 3D cell imaging platform, the Cell-CT™, which generates high-resolution biosignatures from intact cells using a sputum sample.  These biosignatures are automatically analyzed using the company's proprietary predictive analytics to indicate the presence or absence of cancer cells.

The proposed first application of LuCED is as an adjunct to x-ray CT lung cancer screening.  The National Cancer Institute's (NCI) landmark National Lung Screening Trial (NLST) of more than 53,000 current and former smokers showed that low-dose helical CT screening of these high-risk individuals reduced lung cancer deaths by 20% compared to standard chest x-rays.  However, the broad utility of the approach is hampered by the high rate of false positive results seen in the study—according to the NCI, more than 96% of the positive results from low-dose CT screening over three rounds of testing turned out to be false positive findings.  These false positive test results are especially problematic because they require follow-up care that results in unnecessary invasive procedures for many patients and significantly higher costs for the healthcare system as a whole, as well as causing potential psychological trauma to patients.  These results were reported in the August 4, 2011 edition of the New England Journal of Medicine.  

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SOURCE VisionGate, Inc.
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