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Viron reports positive proof of concept results in arthritis for its VT-346 anti-TNF therapeutic
Date:3/16/2010

LONDON, ON, March 16 /PRNewswire/ - Viron Therapeutics Inc. announced that VT-346, an anti-TNF protein therapeutic, demonstrated positive results in a pivotal proof of concept study in the gold standard transgenic mouse model for arthritis. VT-346 achieved a statistically significant, dose dependent impact in this preclinical model of arthritis and prevented deterioration due to disease in terms of weight gain, arthritic score and pathology parameters. VT-346 had particularly strong protective effects on therapeutically-important bone and cartilage damage in this model. The target for VT-346 is the inflammatory cytokine TNF, which is also the target for several biological therapies whose annual sales are expected to top $20 billion in 2010, making anti-TNF therapies the most commercially successful single-target group of biological therapies. Notable, however, is VT-346's unique method of neutralizing TNF, an important mediator of inflammation and therapeutic target in diseases including rheumatoid arthritis, Alzheimer's disease and Crohn's disease.

"The development of an anti-TNF therapy that is fundamentally different from existing therapies offers hope to patients that do not respond adequately to existing anti-TNF drugs," said Dr. Edward Keystone, Head of the Rebecca MacDonald Centre for Arthritis and Autoimmune Diseases and a recognized leader in the development of drugs targeting rheumatoid arthritis. "Approximately 30-50% of patients do not respond optimally to currently available anti-TNF therapies. The potency in pre-clinical studies and unique mechanism by which VT-346 functions could allow clinicians to achie
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SOURCE Viron Therapeutics Inc.
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