Navigation Links
Virobay Appoints David B. Karpf, M.D. as Chief Medicial Officer
Date:11/3/2011

MENLO PARK, Calif., Nov. 3, 2011 /PRNewswire/ -- Virobay, Inc., a privately held biotechnology firm with a broad portfolio of cathepsin protease inhibitors for the treatment of autoimmune diseases, neuropathic pain, liver diseases and cancer, today announced the appointment of David B. Karpf, M.D. as chief medical officer. Dr. Karpf has more than 20 years of experience in guiding the clinical development of novel therapeutics, both at growing biotechnology firms and within large pharmaceutical companies, including all phases of development and spanning multiple therapeutic areas. Dr. Karpf will be responsible for all clinical, regulatory and medical affairs functions related to advancing Virobay's growing pipeline of novel product candidates.  

"David joins Virobay at an exciting time," said Robert Booth, Ph.D., Virobay president and chief executive officer. "With our lead programs in neuropathic pain, autoimmune disease and liver fibrosis and earlier-stage programs in cancer advancing, we are well-positioned to capitalize on the broad therapeutic potential of this important new class of drugs. David's broad industry experience will be invaluable to our progress, and we are pleased to welcome him to the Virobay team."

"Virobay possesses excellent science and high quality research and development assets, combined with a culture of innovation and commitment to advancing differentiated therapies that represent major steps forward in treating serious chronic diseases," said Dr. Karpf. "Cathepsins and calpain are exciting and important new target classes that could yield novel therapies for a number of different important disease indications. I believe that Virobay has the potential to lead this industry effort, and am pleased to join this promising company."

Dr. Karpf brings to Virobay extensive experience in clinical product development, including successful interactions with the FDA and international regulatory agencies.  Dr. Karpf joins Virobay from Metabolex, where he served as chief medical officer and vice president, clinical affairs. While at Metabolex, Dr. Karpf oversaw the development of four clinical programs spanning type 2 diabetes, dyslipidemia, and gout, including 2 INDs, 7 Phase 1 trials and 6 Phase 2 trials.  Prior to Metabolex, Dr. Karpf was executive director of clinical research and regulatory affairs at Geron where he provided oversight for Geron's early clinical programs in cancer and regenerative medicine.  Prior to Geron, Dr. Karpf was vice president, clinical and regulatory affairs at Calydon, Inc.  Prior to his tenure at Calydon, Dr. Karpf was executive director of clinical research at Roche Global Development in Palo Alto and was responsible for clinical development activities in metabolic bone disease and endocrinology, including managing the Phase 3 pivotal program for Boniva™.  Dr. Karpf was previously director of clinical research at Merck Research Laboratories in Rahway, New Jersey.  During his time at Merck he designed, monitored, and completed Phase 2, 3 and 4 clinical trials on Fosamax™ and played a pivotal role in the successful NDA and launch of this product.  In addition to his industry experience, Dr. Karpf has held several academic positions and is currently an adjunct clinical professor of endocrinology with the Stanford University School of Medicine, where he directs one of the endocrine subspecialty clinics.  He received his M.D. degree from University of California, San Diego, served on the fulltime endocrine faculty at UCSF School of Medicine, and has published numerous scientific papers and abstracts in the fields of endocrinology, bone disease, dyslipidemia and cancer.

About Virobay

Virobay is a leader in the design, synthesis and development of small molecule inhibitors of cysteine proteases, a diverse class of enzyme proteases that are key mediators in a variety of diseases, including autoimmunity, neuropathic pain, liver disease, cancer, and cardiovascular disorders.  Virobay was founded upon a rich industry legacy of intensive research and development focused on the cathepsin family of cysteine proteases. Today, Virobay possesses a trove of maturing assets, including an advancing clinical pipeline and well-characterized libraries of highly potent and selective inhibitors with drug-like pharmacokinetics consistent with the potential for oral once-daily dosing in humans.

Virobay's unique expertise in the structure-based design of this class of inhibitors includes extensive understanding of the properties of the cysteine protease active site, detailed knowledge of the cell biology of this enzyme family and a collection of pharmacodynamic biomarkers, as well as a deep understanding of the medicinal chemistry required to achieve superior levels of potency, pharmacokinetics, safety and specificity. Virobay's clinical pipeline currently includes product candidates in autoimmune disease, neuropathic pain and liver fibrosis.  For more information please visit our website: www.virobayinc.com.


'/>"/>
SOURCE Virobay, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Axia Value Chain Appoints John Christina Managing Director of Life Sciences Practice
2. Marshall Edwards Appoints Healthcare Investment Banking Veteran Charles Baltic to Board of Directors
3. Metabolex Appoints Raymond Urbanski M.D., Ph.D. to Position of Chief Medical Officer
4. Amgen Appoints Anthony (Tony) Hooper Executive Vice President Global Commercial Operations
5. Kessler Foundation Appoints New Director of Human Performance and Engineering Laboratory
6. China Botanic Appoints Zack Zibing Pan as an Independent Director and Chairman of its Audit Committee
7. Immune Design Corp. Appoints Guy F. Cipriani as Chief Business Officer
8. Amgen Appoints Robert A. Bradway to the Companys Board of Directors
9. PrimeraDx Appoints Jeff Liter as VP of Corporate Development
10. Oncobiologics Appoints Scott Canute, Former President of Eli Lilly and Genzyme, to its Board of Directors
11. PharmaVentures Appoints Andy Smith as Head of Corporate Finance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... ... October 11, 2017 , ... ... and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... maternal age to IVF success. , After comparing the results from the fresh ...
(Date:10/10/2017)... , ... October 10, 2017 , ... Dr. Bob Harman, ... his local San Diego Rotary Club. The event entitled “Stem Cells ... and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by two human ...
(Date:10/9/2017)...  BioTech Holdings announced today identification and patenting ... stem cell therapy prevents limb loss in animal ... that treatment with ProCell resulted in more than ... to standard bone marrow stem cell administration.  Interestingly, ... of therapeutic effect.  ...
(Date:10/7/2017)... ... October 06, 2017 , ... With ... microscopy and surface analysis, Nanoscience Instruments is now expanding into Analytical Services. ... range of contract analysis services for advanced applications. Services will leverage techniques ...
Breaking Biology Technology:
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/23/2017)... India , March 23, 2017 The report "Gesture ... Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by MarketsandMarkets, ... at a CAGR of 29.63% between 2017 and 2022. ... ... ...
Breaking Biology News(10 mins):