Navigation Links
ViiV Healthcare Starts Phase III Clinical Programme of Celsentri/Selzentry® (maraviroc) versus Truvada® (tenofovir + FTC), in combination with a Protease Inhibitor in people living with HIV
Date:10/11/2011

LONDON, Oct. 11, 2011 /PRNewswire/ -- ViiV Healthcare announces the start of the Phase III MODERN Study [Maraviroc Once daily with Darunavir Enhanced by Ritonavir in a Novel regimen], also known as A4001095, comparing its CCR5-inhibitor, Celsentri/Selzentry® (maraviroc), to emtricitabine/tenofovir (Truvada®), both in combination with darunavir/ritonavir. The 96-week trial will evaluate a two-drug versus three-drug once-daily regimen for the treatment of antiretroviral-naive patients infected with CCR5-tropic HIV-1.

"The treatment of HIV has come a long way, but it is essential that we continue to pursue effective novel treatment strategies that minimise toxicity while maximising tolerability and convenience. The MODERN study will investigate a treatment approach using Celsentri that is designed to meet those goals," said Dr. John Pottage, Chief Scientific and Medical Officer, ViiV Healthcare. "ViiV Healthcare is committed to understanding patient needs and addressing them through innovative treatment approaches that directly reflect what we learn."

Exploration of HIV treatment regimens that don't include a nucleoside reverse transcriptase inhibitor (NRTI), currently recommended as part of standard of care for first line HIV therapy, continues to be an area of interest because of the potential to alleviate some long-term toxicities associated with NRTI-based regimens and preserve future treatment options.  

About MODERNMODERN is a Phase III, 96-week, multi-center, randomised, double-blind, comparative study. It will include approximately 804 antiretroviral-naive patients infected with CCR5-tropic HIV-1 from over 250 sites in the E.U., U.S. and Australia. The primary endpoint for MODERN is the proportion of patients with HIV-1 RNA <50 copies/mL at week 48. Secondary objectives include the proportion of patients with HIV-1 RNA below the limits of assay detection at week 96; change in CD4+ and CD8+ cell counts through 48 an
'/>"/>

SOURCE ViiV Healthcare
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. MSC to Offer Surgical Implant Cost Management Solution through Acquisition of Integrated Healthcare Services
2. Medicalbillersandcoders.com Offers Effective Ways to Combat Healthcare Fraud and Abuse in California, Florida, and Michigan
3. Halozyme Therapeutics to Present at the JMP Securities Healthcare Conference on September 28
4. GNS Healthcare, Inc Collaborates with Nationally Ranked Hospital to Predict Adverse Drug Events and Hospital Readmissions
5. Tengion to Present at Rodman & Renshaw 13th Annual Healthcare Conference
6. Anadys Pharmaceuticals Updates Its Presentation Date at the Stifel Nicolaus Healthcare Conference
7. Chimerix to Present at Stifel Nicolaus 2011 Healthcare Conference
8. Omeros to Present at Rodman and Renshaw 13th Annual Healthcare Conference
9. Neuralstem President and CEO to Present at the 2011 Stifel Nicolaus Annual Healthcare Conference
10. Auxilium Pharmaceuticals to Present at the Morgan Stanley 2011 Healthcare Conference
11. PAREXEL International to Present at Robert Baird Healthcare Conference and William Blair Emerging Growth Stock Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... City, CA (PRWEB) August 28, 2014 ... sanitation products for the food processing industry, is asking ... a side-by side comparison of the E2 soap they’re ... E2 Sanitizing Foam Soap . Hand hygiene is ... in the food processing environment. Six key criteria are ...
(Date:8/28/2014)... August 28, 2014 Best Sanitizers, Inc., ... an alcohol-based hand sanitizer, asks food processors and food ... the hand sanitizer they’re currently using to Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... Sanitizers believes there are key criteria that make a ...
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides ... ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for Charm ... and USDA-GIPSA inspection agencies that have a need to detect ... in a matter of minutes with nothing but our equipment ... and grain before accepting it, but they no longer have ...
(Date:8/28/2014)... Ind. A new research platform uses ... of tiny structures undergoing stress and heating, ... improve designs for microelectronics and batteries., This ... information about how heating and the surface ... properties. Researchers have discussed the merits of ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3
... SGMO ) announced today that Edward Lanphier, ... progress of Sangamo,s ZFP Therapeutic,development programs and an overview ... Tuesday, December 2, 2008 at the Piper Jaffray 20th ... will also update the,financial community on its latest developments ...
... , , HUNTINGTON, W. Va.,Nov. ... attract new biotechnology companies and assist them in bringing new ... Area Development Council (HADCO) is creating a biotech incubator with ... , , The incubator, which ...
... products with the HERCULEX® XTRA traits are now eligible for crop ... ... Des Moines, IA and Indianapolis, IN (Vocus) November 25, 2008 ... HERCULEX® XTRA traits are now eligible for crop insurance ...
Cached Biology Technology:Sangamo BioSciences to Webcast Annual Investor and Analyst Briefing and Presentation at Piper Jaffray Health Care Conference 2Huntington Area Development Council Attracts Technology-Based Startup Companies With $150,000 Grant From Verizon West Virginia 2Biotech Endorsement Insurance Discount Expanded to Nebraska, Kansas Growers Planting Corn with HERCULEX XTRA Traits 2Biotech Endorsement Insurance Discount Expanded to Nebraska, Kansas Growers Planting Corn with HERCULEX XTRA Traits 3
(Date:8/27/2014)... mastodons, short-faced bears, giant ground sloths, saber-toothed cats and ... years ago at the end of the Pleistocene period. ... debated by scientists who, until recently, could only speculate ... UC Santa Barbara,s James Kennett, professor emeritus in the ... with Earth played a major role in the extinction. ...
(Date:8/27/2014)... University researchers have identified a gene that could help ... a protein in the cell membrane of plants that ... water conservation machinery accordingly. , "It,s similar to ... biology at Duke. , The findings, which appear ... make it easier to feed the world,s growing population ...
(Date:8/27/2014)... PITTSBURGHLearning a new skill is easier when it is ... a trained pianist might learn a new melody more ... , Neural engineers from the Center for the Neural ... of Pittsburgh and Carnegie Mellon Universityhave discovered a fundamental ... happens. Published as the cover story in the Aug. ...
Breaking Biology News(10 mins):Nanodiamonds are forever 2Nanodiamonds are forever 3Water 'thermostat' could help engineer drought-resistant crops 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3
... Director of the Lawson Health Research Institute and Professor ... School of Medicine & Dentistry at The University of ... in biology from rebro University in Sweden. ... award and the only recipient this year in the ...
... beliefs, identical twins are not genetically identical. This ... scientists in a study being published today in the ... finding may be of great significance for research on ... methods. How can it be that one identical ...
... growth of pancreatic cancer could lead to a new ... College of Medicine in Houston in a report appearing ... Therapeutics. The protein called mesothelin appears to play ... the senior author Dr. Qizhi (Cathy) Yao, professor of ...
Cached Biology News:Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer 2