Video: CSL Behring Provides $1.2M Grant for World's First Study of Postpartum Women with VWD, Common Bleedin...(ive cohort study will compare changes in...)

Date:8/18/2008

ive cohort study will compare changes in blood levels of von Willebrand factor proteins postpartum between 40 women with and 40 women without VWD. At periodic intervals in the immediate postpartum period, von Willebrand Factor: Ristocetin cofactor activity (VWF:RiCoF), factor VIII (FVIII) and von Willebrand factor antigen (VWF:Ag) levels will be measured. The study will seek to determine how quickly, to what levels, and for how long VWF levels decline in the days after delivery. The study will also determine how postpartum bleeding in women with VWD correlates with VWF levels.

About von Willebrand Disease

Von Willebrand disease is caused by a deficiency or abnormality of the von Willebrand factor, a protein in the blood that is necessary for normal blood clotting. Men and women are equally likely to be affected by VWD. VWD is classified by types, ranging from Type I (the most common and mild) to Type III (the most severe).

Women with VWD are more likely to experience heavy, prolonged menstruation. Other common symptoms of VWD include frequent nosebleeds and easy bruising. Bleeding can be mild or serious and can occur as a result of injury, or without any obvious cause. More serious symptoms include bleeding into joints and internal organs. The VWD patient may require special care during dental procedures, surgery and childbirth.

Treatments for VWD may include desmopressin acetate to release von Willebrand factor the patient has stored in their cells; von Willebrand factor replacement therapies, and oral contraceptives to reduce menstrual bleeding and raise von Willebrand factor in the bloodstream. Antifibrinolytic therapies are also used successfully to treat menorrhagia.

About CSL Behring

CSL Behring is a global leader in the plasma protein biotherapeutics industry. Passionate about improving the quality of patients' lives, CSL Behring manufactures and markets a range of safe and effective plasma-derived and recombinant pro
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SOURCE CSL Behring Copyright©2008 PR Newswire. All rights reserved

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