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Vical Licensee AnGes MG Files NDA in Japan for Collategene Angiogenesis Product
Date:3/28/2008

opment went ahead in Japan first.

Since last June, when we got the positive results at the interim analysis of our Phase III study in Japan for ASO patients with CLI, we have prepared for submission, and are pleased to be the first company in Japan to submit an NDA for a gene therapy product.

AnGes is aiming to provide this product to patients also worldwide. After approval, the brand name in Japan will be "Collategene". The name comes from the meaning of formation of "collateral vessels" by angiogenesis and improvement of ischemic symptoms by "gene therapy".

About Vical

Vical researches and develops biopharmaceutical products based on its patented DNA delivery technologies for the prevention and treatment of serious or life-threatening diseases. Potential applications of the company's DNA delivery technology include DNA vaccines for infectious diseases or cancer, in which the expressed protein is an immunogen; cancer immunotherapeutics, in which the expressed protein is an immune system stimulant; and cardiovascular therapies, in which the expressed protein is an angiogenic growth factor. The company is developing certain infectious disease vaccines and cancer therapeutics internally. In addition, the company collaborates with major pharmaceutical companies and biotechnology companies that give it access to complementary technologies or greater resources. These strategic partnerships provide the company with mutually beneficial opportunities to expand its product pipeline and address significant unmet medical needs. Additional information on Vical is available at http://www.vical.com.

This press release contains forward-looking statements subject to risks and uncertainties that could cause actual results to differ materially from those projected. Forward-looking statements include statements about the potential approval of Collategene, as well as Vical's focus, collaborative partner
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SOURCE Vical Incorporated
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