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Vermillion and Collaborators Discover Protein Biomarker Associated with Peripheral Artery Disease
Date:8/28/2007

- Potential Biomarker for Early and Accurate Diagnosis of Peripheral Artery

Disease -

- Findings Published Online in Circulation -

FREMONT, Calif., Aug. 28 /PRNewswire-FirstCall/ -- Vermillion, Inc. (Nasdaq: VRML), formerly Ciphergen Biosystems, today announced the publication of research that details how a protein biomarker called beta-2 microglobulin may aid in the diagnosis of peripheral artery disease (PAD). The findings, which suggest beta-2 microglobulin is elevated in patients with PAD and that the level of the protein is correlated with the severity of the disease, will be published during September in Circulation and is currently online at http://circ.ahajournals.org/.

Working with scientists at Stanford University, Vermillion intends to develop a blood test for the diagnosis of PAD and the Company's development program is aimed at identifying and commercializing a panel of novel biomarkers, which includes the newly discovered role of beta-2 microglobulin.

"Peripheral artery disease is a common disease, affecting approximately 10 million Americans. Unfortunately, PAD is commonly unrecognized in patients," said John Cooke, MD, PhD, Professor of Medicine at Stanford University and senior author on the paper. "Patients with PAD are at high risk of heart and vessel complications unless they receive preventative treatment. A blood test would be useful to identify individuals who are at risk for the condition and triage them to further testing."

Over 370 patients at risk of PAD were intensively studied using questionnaires, blood tests, treadmill exercise, limb blood pressures and coron
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SOURCE Vermillion, Inc.
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