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Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
Date:10/24/2008

on to large numbers of people," said Dr. Arnold Monto, professor of epidemiology at University of Michigan. "The availability of an oral vaccine for annual influenza would also likely improve vaccination compliance and help reduce the rates of hospitalization and death that are associated with flu every year."

The Vaxart Approach

Vaxart has developed a proprietary, modular approach to vaccine development that will reduce the time and expense needed to bring new vaccines to market. The key to Vaxart's efforts is a unique adjuvant (an adjuvant is the vaccine component that enhances immune response to a foreign protein). Vaxart uses an adjuvant that works through a "toll-like receptor" (TLR). Vaxart determined that TLR3 is much more active in the gut than other TLR pathways that have been used for injected vaccines, making this the only TLR adjuvant approach likely to work well for oral vaccines. The company has demonstrated both the induction of mucosal immunity and the stimulation of antigen-specific cell-based immunity following oral administration of its vaccines; these features may provide a performance advantage over injected protein vaccines.

Another key feature of the Vaxart platform is the ability to employ the same vector (delivery vehicle) across all vaccines. Typically an injected vector can only be used once, because antibodies build up against the vector proteins after initial exposure. Subsequent vaccines are less effective, because the body neutralizes the vector before a response can be mounted against the disease target. Vaxart has overcome this obstacle and demonstrated that strong immune responses can be generated against multiple diseases following a series of different oral vaccines. Vaxart will be able to produce new vaccines through a standardized and low-cost process, and safety data from one vaccine will be supportive for others created through the platform.

About Vaxart

Vaxart (

SOURCE Vaxart Inc.
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