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Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
Date:10/24/2008

- Using proprietary platform, company develops first orally-administered

vaccine to protect against avian influenza in a large-animal model -

SAN FRANCISCO, Oct. 24 /PRNewswire/ -- Vaxart Inc., a biotechnology company focused on the development of oral vaccines, today announced positive efficacy results from preclinical studies of the company's oral avian flu vaccine. Sean Tucker, PhD, Vaxart founder and vice president of research, presented data from animal models demonstrating that an orally administered flu vaccine was protective against lethal exposure to H5N1 influenza. Tucker presented the data this morning at the Modern Mucosal Vaccines, Adjuvants & Microbicides (MMVAM) international conference in Porto, Portugal.

Delivery of flu vaccine via a capsule rather than an injection offers critical advantages, particularly in the case of a pandemic. The Vaxart vaccine formulation can withstand ambient temperatures, enabling emergency distribution methods that avoid the transmission risks associated with centralized vaccination clinics. In the developing world, where medical providers and supplies are scarce, oral vaccination will reduce costs, as well as needle reuse and consequent cross-infection.

The data presented today are from studies measuring the effectiveness of an orally-administered avian flu vaccine designed by Vaxart scientists using the company's proprietary modular platform. The Vaxart vaccine (ND1) comprises a non-replicating chimeric adenovirus-5 vector, or delivery vehicle, engineered to express avian flu hemaggluttinin (HA) and a TLR3 ligand as a vaccine adjuvant.

"Injected vector-based vaccines that deliver a target pathogen protein have shown excellent potency in animal models, but their application has been limited in humans because the immune system typically responds to the vector rather than the target," said Dr. Tucker. "By using oral delivery of a non- replicating vector with a potent adjuvant, we achi
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SOURCE Vaxart Inc.
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