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Vascular Biogenics Ltd. Presented With the Frost & Sullivan 2008 European Gene Expression Targeting Platform Technology Innovation Award
Date:8/26/2008

MOUNTAIN VIEW, Calif., Aug. 26 /PRNewswire/ -- The 2008 European Gene Expression Targeting Platform Technology Innovation Award is presented to Israel-based Vascular Biogenics Ltd. for developing the Vascular Targeting System (VTS(TM)). This unique platform has facilitated novel advancements in gene expression-based treatments where angiogenesis is an explicit feature.

"The VTS(TM) platform is a potent and flexible technology permitting the limitation of gene expression to endothelial cells undergoing angiogenesis," explains Frost & Sullivan Research Analyst Prasanna Vadhana Kannan. "The uniqueness of the VTS(TM) platform can be utilised for the technological advancement and commercialisation of novel treatments targeting life-threatening diseases where angiogenesis occurs."

The innovative gene expression targeting platform technology essentially facilitates control of gene expression to the zones where angiogenesis is taking place to either promote the formation or destroy the newly formed blood vessels. It represents a promising tool for targeted treatment of pathological diseases, supported by the effective delivery of therapies solely to diseased tissues, avoiding harm to the body's healthy tissues.

Till date, the VTS(TM) platform has been used in generating two chief therapeutic drug candidates mainly dependent upon inserted genes, pro-apoptotic and pro-angiogenic signals. The two developmental products based on the VTS(TM) technology are GT-111, an anti-angiogenic cancer therapy, which has the potential to be utilised as a relatively broad-spectrum anticancer agent effective in different types of solid tumours where vascularisation is of primary concern and GT-211, which is a pro-angiogenic therapy for ischemic diseases.

"Both products are ideally designed for effectively stimulating the growth and maturity of new blood vessels, thus aiding in enhancing the VTS(TM) platform's efficacy in thwarting areas that suffer from lack
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SOURCE Frost & Sullivan
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