Navigation Links
Van Andel Research Institute Study Provides New Details of Fundamental Cellular Process
Date:1/23/2012

GRAND RAPIDS, Mich., Jan. 23, 2012 /PRNewswire/ -- A recent Van Andel Research Institute (VARI) study published in the journal Science investigating the molecular structure and function of an essential plant hormone could profoundly change our understanding of a key cell process, and might ultimately lead to the development of new drugs for a variety of diseases.

The study builds on earlier work by the same team of investigators at VARI that was published in the journal Nature in 2009. That study shed light on how plants respond when they are under stress from extreme temperatures, drought and other harsh environmental conditions and was later named by Science as one of the top scientific breakthroughs of 2009.

The current research conducted on the plant hormone Abscisic acid (ABA) determined that during signal transduction – the basic process of intercellular and intracellular communication – certain enzymes mimic the structure of the opposing enzyme. This insight may enable scientists to more accurately develop mechanisms to activate or inhibit intercellular and intracellular communication, which could lead to the development of plants that more readily survive drought or other conditions of stress.

In mammalian cells the ability to impact communication has numerous and far-reaching implications.  For example, applications that inhibit or activate cell communication in out-of-control metastasizing cancer cells have enormous potential to affect tumor growth.

"This type of finding once again demonstrates the importance of identifying, mapping and understanding fundamental cellular and molecular processes because of the profound implications for human health," said H. Eric Xu, Ph.D., Director of the VARI Center for Structural Biology and Drug Discovery and co-author of the current Science study.

The lead authors of the current Science study are Fen-Fen Soon, Ley-Moy Ng, and Edward Zhou. The project was carried out in conjunction and collaboration with scientists from the National University of Singapore, Purdue University, The Scripps Research Institute, Scripps Florida, Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, the Synchrotron Research Center of Northwestern University, and University of California at Riverside.

Link to the full release on www.vai.org

Link to the study and to a Science editorial discussing it here:

http://www.sciencemag.org/content/335/6064/85.abstract

http://www.sciencemag.org/content/335/6064/46.full

www.vai.org
Facebook 
Twitter 
YouTube 

 


'/>"/>
SOURCE Van Andel Research Institute
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. LI-COR Biosciences and Mandel Scientific Company Inc. Announce Distribution Agreement
2. Van Andel Institute Joins the MetaMiner Oncology Partnership Program
3. Andrew P. Mandell - Mr. Diabetes(R) to Sit On ProtoKinetix Advisory Board
4. Takeda and Zinfandel Pharmaceuticals Sign Licensing Agreement for Alzheimers Disease Biomarker in Combination with Pioglitazone
5. Van Andel Institute Earns Highest "Green Building" Award
6. Dr. Lester Mandelker to Collaborate with Nuovo Biologics, LLC
7. Sandell Asset Management Seeks Sale of Rubicon & Tenon, Expansion of Board
8. Candelis and Microsoft Team Up to Empower Patients
9. Van Andel Institute Partners with UNCF to Recruit Students to Biomedical Research Careers
10. NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes
11. Canopus Biopharma and Leading Chinese Researcher Team Up to Treat Avian Influenza, to Prevent Possible Pandemic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology ... drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription ... is able to cross the cell membrane and bind intracellular STAT3 and inhibit ...
(Date:10/10/2017)... California (PRWEB) , ... October 10, 2017 , ... Dr. ... speaking at his local San Diego Rotary Club. The event entitled ... Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined by ...
(Date:10/10/2017)... ... 10, 2017 , ... The Pittcon Program Committee is pleased ... scientists who have made outstanding contributions to analytical chemistry and applied spectroscopy. Each ... leading conference and exposition for laboratory science, which will be held February 26-March ...
(Date:10/9/2017)... Phoenix, Arizona (PRWEB) , ... October 09, 2017 ... ... of Kindred, a four-tiered line of medical marijuana products targeting the needs of ... production and packaging of Kindred takes place in Phoenix, Arizona. , As operators ...
Breaking Biology Technology:
(Date:6/14/2017)... PARIS , June 15, 2017  IBM (NYSE: IBM ... the international tech event dedicated to developing collaboration between startups ... on June 15-17. During the event, nine startups will ... deliver value in various industries. ... in the international market, with a 30 percent increase in ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
(Date:4/17/2017)... April 17, 2017 NXT-ID, Inc. (NASDAQ: ... the filing of its 2016 Annual Report on Form 10-K on ... ... is available in the Investor Relations section of the Company,s website ... SEC,s website at http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):