Navigation Links
Valeant Pharmaceuticals Reports Encouraging Final Results With Taribavirin Phase IIb Study
Date:6/1/2009

ALISO VIEJO, Calif., June 1 /PRNewswire-FirstCall/ -- Valeant Pharmaceuticals International (NYSE: VRX) today reported final results for its Phase IIb dose-finding clinical trial for taribavirin, a prodrug of ribavirin which is in development for the treatment of chronic hepatitis C in conjunction with a pegylated interferon. The study in treatment naive genotype 1 infected subjects was of standard design, consisting of 48 weeks of treatment with a 24-week follow-up period. It explored three weight-based doses of taribavirin: 20 mg/kg, 25 mg/kg and 30 mg/kg vs. ribavirin 800-1400 mg/day. Throughout the 72-week trial, all doses of taribavirin demonstrated comparable efficacy (sustained virologic response (SVR)) to ribavirin with consistently lower levels of anemia. In addition, relapse rates in the 25 mg/kg and 30 mg/kg arms were comparable with the ribavirin arm; supporting the premise that higher dose weight-based taribavirin may be as effective as weight based ribavirin. Valeant plans to present the full final data at the American Association for the Study of Liver Disease (AASLD) later this year.

"The final results of this Phase II study are promising and imply that comparable efficacy with taribavirin can be achieved when compared to ribavirin," stated Fred Poordad, M.D., Chief of Hepatology at the Center for Liver Disease and Transplantation, Cedars-Sinai Medical Center, Los Angeles, CA. "As is known for ribavirin, low doses are associated with a high relapse rate and, except for the lowest dose with taribavirin, relapse rates are also comparable to ribavirin. The safety of this ribavirin analog is of particular relevance in the evolving era of small molecule therapies as anemia appears to be more problematic."

"We are very pleased with the results from this dose finding study which confirms th
'/>"/>

SOURCE Valeant Pharmaceuticals International
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. DFB Sells Coria Labs to Valeant Pharmaceuticals
2. Valeant to Acquire Dow Pharmaceutical Sciences, Inc. for $285 Million
3. Valeant Pharmaceuticals Completes Acquisition of Dow Pharmaceutical Sciences, Inc.
4. Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes
5. China Biopharmaceuticals Holdings Announces Second Quarter 2007 Financial Results
6. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
7. XTL Biopharmaceuticals Announces Financial Results for the Six Months Ended June 30, 2007
8. Cadence Pharmaceuticals Reports Second Quarter 2007 Financial Results
9. Nabi Biopharmaceuticals to Present at Upcoming Industry Conferences
10. Anadys Pharmaceuticals Appoints Steve Worland, Ph.D. as President and Chief Executive Officer
11. Poniard Pharmaceuticals Announces Participation in Upcoming Conferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... Immunocore Limited, a world-leading ... cancer, viral infections and autoimmune disease, today announced ... , the Regius Professor of Medicine at Oxford ... Strategic Coordination of Health Research, to its Board ... (Photo: http://photos.prnewswire.com/prnh/20150330/736483 ) , ...
(Date:3/29/2015)... , March 29, 2015  Caris Life ... in which Caris Molecular Intelligence®, the company,s panomic, ... and differences between several rare and difficult to ... that have the potential to improve patient outcomes. ... B at the Society of Gynecologic Oncology (SGO) ...
(Date:3/27/2015)... Cranston, RI (PRWEB) March 27, 2015 ... for the promotion of hair regrowth in adult ... Savin classifications I-II or Norwood Hamilton classifications of IIa-V ... In an industry plagued by products that over-promise and ... the Capillus272Pro™, renewing faith and confidence among more than ...
(Date:3/27/2015)... March 27, 2015   SurePure, Inc . ... announced today that the Company has completed the ... trading of SurePure ("SURP") securities on OTCQB, an ... entrepreneurial and development stage companies. On ... and eligibility requirements designed to improve marketplace integrity ...
Breaking Biology Technology:Immunocore Appoints Professor Sir John Bell to its Board of Directors 2Immunocore Appoints Professor Sir John Bell to its Board of Directors 3Immunocore Appoints Professor Sir John Bell to its Board of Directors 4Immunocore Appoints Professor Sir John Bell to its Board of Directors 5Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 2Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 3Caris Molecular Intelligence Facilitates Comparison of Biomarker Profiles to Inform Targeted Treatment Strategies in Distinct Gynecological Cancers 4Dr. Robert Leonard Applauds FDA Clearance of Capillus272Pro™ Hair Loss Laser Cap 2SurePure Completes Verification and Approved for Trading on the OTCQB Marketplace 2
... Lydford 1 and Thomas Giller 2 , 1 ... , INTRODUCTION , GFP (Green Fluorescent ... by the jellyfish Aequorea victoria 1 that fluoresces ... past few years GFP has become one of the most widely ...
... Anna Lam, B.S., ... 8/99 , , INTRODUCTION , ... or flu-orogenic peptide substrates. Enzyme selectivity is obtained by choosing ... a particular enzyme. The chromophore or fluorophore is attached near ...
... , A Sensitive, Robust, Homogenous,and Rapid Assay , ... method , Assays a broad range of tyrosine kinases ... in a kit and in bulk packaging , , ... activity can be accelerated using High Efficiency Fluorescence Polarization ...
Cached Biology Technology:Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44) 2Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44) 3Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44) 4Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44) 5Measurement of Green Fluorescent Protein in the SpectraMax Gemini XS Spectrofluorometer (MaxLine Application Note #44) 6Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35) 2Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35) 3Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35) 4Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35) 5Fluorometric Protease Assays in the SpectraMax Gemini Microplate Spectrofluorometer: Example Using Caspase3 (MaxLine Application Note #35) 6TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization 2TKXtra DataFile: Homogenous tyrosine kinase detection using High Efficiency Fluorescence Polarization 3
(Date:3/17/2015)... 17, 2015  MecklerMedia Corporation (OTCQX: MECK) announced ... service robots ever held in New ... May 11-13, 2015 at the Javits Convention Center. ... event include: Acorn Product Development; Axis NJ; c-Link ... Robotics; Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; ...
(Date:3/12/2015)... March 12, 2015 Beta ... identity and access management (IAM) solution for a ... With Beta System,s new IAM package, customers benefit ... gleaned from multiple IAM implementations across different industries. ... as well as any necessary services and consulting. ...
(Date:3/10/2015)... 2015  Continuing its 167-year history of offering the ... The Eye Scanning Password Authenticator , a device ... secure websites or sensitive data. Employing the ... borders, the device has a small camera that scans ... iris, converting them into an encrypted ID that cannot ...
Breaking Biology News(10 mins):MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2
... Rockville, Md., November 12, 2007 On September 10, ... several multivitamin supplements did not contain label amounts of ... by IVC, Industries, Inc., is part of U. S. ... USP Verified mark. In response to the report, USP ...
... ARTICLE #1 FOR IMMEDIATE RELEASE Toward cancer ... Bioconjugate Chemistry A new drug-delivery system for cancer of ... to treat has the potential to carry anticancer ... researchers in Connecticut and New York report. Their study ...
... Eating too much fructose and glucose can turn off the ... in the body, shows a new study in mice and ... of Clinical Investigation. This discovery reinforces public health advice to ... of glucose and fructose, while fructose is also commonly used ...
Cached Biology News:Market testing of dietary supplements and drugs underscores value of USP's public health programs 2American Chemical Society's Weekly PressPac -- Nov. 7, 2007 2American Chemical Society's Weekly PressPac -- Nov. 7, 2007 3American Chemical Society's Weekly PressPac -- Nov. 7, 2007 4American Chemical Society's Weekly PressPac -- Nov. 7, 2007 5American Chemical Society's Weekly PressPac -- Nov. 7, 2007 6American Chemical Society's Weekly PressPac -- Nov. 7, 2007 7American Chemical Society's Weekly PressPac -- Nov. 7, 2007 8American Chemical Society's Weekly PressPac -- Nov. 7, 2007 9Too much sugar turns off gene that controls the effects of sex steroids 2
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
Human SDNSF/MCFD2 Biotinylated Affinity Purified PAb...
... kit. Facilitates the simple, phenol-free extraction of ... tissue requiring proteinase K digestion.Each kit is ... 50 preparations of up to 25 mg ... Purification, Purification and Amplification of Genomic DNA, ...
Homo sapiens alcohol dehydrogenase 5 (class III), chi polypeptide (ADH5), mRNA....
Biology Products: