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Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe
Date:2/24/2009

(18-65 years old) presenting a first or recurrent episode of depression(2) - Valdoxan has demonstrated efficacy at every step of depression treatment, showing superior clinical improvement within the first week of treatment, as reported by both physicians and patients(3),(4) - Valdoxan is effective against all the core symptoms of depression, including depressed mood, anxiety, feeling of guilt, psychomotor retardation, sleep disturbances, and daytime fatigue, leading depressed patients to a more complete and sustained remission(5) - Valdoxan has been proven to significantly reduce the incidence of relapse in depressive patients over the long term(4) - Valdoxan preserves sexual functioning, is weight neutral and offers a favourable tolerability profile, thus resulting in better adherence and remission in depressed patients(6) - Valdoxan is easy to use from beginning to end: a simple dose of one 25 mg tablet taken orally at bedtime, without discontinuation symptoms at the end of treatment.(7)

"Valdoxan has the potential to relieve the symptoms of depression with a reduced risk of significant adverse effects," said Professor Goodwin. "With noticeable clinical improvement as early as the first week of treatment, Valdoxan represents an advance for depressed patients who today expect a more complete remission."

Valdoxan: a major therapeutic advance in management of depression through the restoration of circadian rhythms

Valdoxan is the result of an advanced pharmacological research programme involving investigation centres all around the world. It is the first antidepressant that simultaneously acts as a MT1 and MT2 melatonergic receptors agonist and a 5-HT2C antagonist. As a result, Valdoxan resynchronises circadian rhythms that are profoundly disrupted in depressed patients.(8)

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