Navigation Links
Vaginal Ring Provides “Radically New” Drug Delivery Platform for Health Issues, Including Infertility
Date:6/25/2013

Austin, TX (PRWEB) June 25, 2013

Fertility medications help women produce and release eggs and fortify the uterus to sustain a pregnancy, but the delivery method can be painful. Some women endure as many as 90 shots in one cycle of fertility treatment, including intramuscular injections of a thick progesterone compound that continue throughout the first trimester of pregnancy. Texas Fertility Center and Dr. Kaylen Silverberg recently published a research study that may offer patients significant relief.

The study http://www.fertstert.org/current found that pregnancy rates using a vaginal ring (similar to one currently used as a form of birth control) were not significantly different than those achieved with either progesterone vaginal gel or intramuscular injections. Study participants were evaluated by both cause and duration of infertility, with the primary study goal being to compare the effectiveness of two different delivery methods--vaginal gel and the vaginal ring--for the fertility drug progesterone.

“We were not surprised that women preferred the vaginal ring to intramuscular injections,” Dr. Silverberg said. “In addition to the convenience of administering medication once weekly versus daily shots or daily vaginal gel, combined with the comfort factor, this radically new drug delivery method will increase the effectiveness of progesterone and decrease side effects because it bypasses the normal breakdown that occurs in the liver or in the intestine.”

Dr. Silverberg recently traveled to Jerusalem, Israel to participate in an international advisory board meeting with ObGyns and fertility specialists from around the world at Teva Pharmaceutical Industries Ltd.’s global headquarters. Teva is the manufacturer of the Milprosa™ (Progesterone) Vaginal Ring, now in clinical trials.

In independent research, Texas Fertility Center physicians concluded that the progesterone vaginal ring is effective for luteal phase supplementation in IVF, regardless of the duration or cause of infertility.

Progesterone, a hormone naturally produced to nourish and prepare the uterine lining, has a critically important role in helping to sustain pregnancy. During the in vitro fertilization process, the cells that make progesterone are removed from the ovarian follicles along with the eggs. Fertility specialists must then prescribe progesterone to supplement the significantly reduced amount of progesterone produced by a woman’s ovaries after IVF egg retrieval.

Progesterone delivered vaginally now represents over 65 percent of all IVF-related progesterone usage in the US. The multi-center study that TFC participated in demonstrated – for the first time - that the new vaginal progesterone-secreting ring works as well as the leading vaginal gel.

Comparing the New Vaginal Ring to Gels and Injections

1.    Vaginal progesterone gel: Less painful and easier to administer than injections, once or twice daily dosing, may be messy, and due to potential leakage, may not provide a full dose with every application.

2.    Progesterone vaginal ring: The flexible silicone product, inserted into the vagina, contains a micronized progesterone formulated to allow for weekly dosing. Although it occasionally caused mild discomfort, it was generally well tolerated by study participants.

3.    Progesterone injections: Administered once or twice daily. Very painful and potentially may cause injection site inflammation or infection. Serum progesterone levels are highest with intramuscular administration, but because of the uterine first pass effect, vaginal administration may result in higher uterine progesterone levels.

“The vaginal ring as a medication delivery platform represents an exciting breakthrough with staggering implications. In addition to progesterone, there is the potential for the delivery of other medications through this novel system,” Dr. Silverberg added.

About Texas Fertility Center

Texas Fertility Center (TFC), one of the nation’s leading full-service infertility practices, provides advanced Infertility and Reproductive Endocrinology services to patients throughout Texas, the Southwestern United States, and the Americas. Since 1980, TFC has been recognized nationally for outstanding pregnancy rates, cutting-edge laboratory procedures, and innovative research programs. For more information, please visit http://www.txfertility.com.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10835424.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Home field advantage: Intravaginal immunization may help protect against infection
2. FDA Advisory Committee Declines to Recommend Approval of Progesterone Vaginal Gel 8% for the Reduction of Risk of Preterm Birth in Women with Short Uterine Cervical Length
3. Cempra Provides Guidance on the Clinical Program Required for Regulatory Approval for Solithromycin for Community-Acquired Bacterial Pneumonia (CABP)
4. The Hemostemix Group of Companies Provides Corporate Strategy Update
5. Study led by GW professor provides better understanding of waters freezing behavior at nanoscale
6. Yongye International Provides Update on Status of Proposed Go Private Offer
7. Neuralstem Reports First Quarter Financial Results And Provides Business And Clinical Update
8. BioDelivery Sciences Provides Business Review and Update in Conjunction with Filing of First Quarter 2013 Financials
9. Celsion Corporation Reports First Quarter 2013 Financial Results and Provides Business Update
10. Adamis Pharmaceuticals CEO Provides Update for Shareholders
11. Cellular Biomedicine Group Provides Update and 2013 Milestones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... , ... October 10, 2017 , ... ... and business process optimization firm for the life sciences and healthcare industries, announces ... conference in San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud ...
(Date:10/9/2017)... Jupiter, FL (PRWEB) , ... October 09, 2017 , ... ... episode, scheduled to broadcast first quarter 2018. American Farmer airs Tuesdays at 8:30aET on ... Agriculture industry is faced with the challenge of how to continue to feed a ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses the ... in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The prospective ...
(Date:10/7/2017)... Mass. , Oct. 6, 2017  The ... work of three scientists, Jacques Dubochet, Joachim ... breakthrough developments in cryo-electron microscopy (cryo-EM) ... technology within the structural biology community. The winners ... Scientists can now routinely produce highly resolved, three-dimensional ...
Breaking Biology Technology:
(Date:5/23/2017)... 23, 2017  Hunova, the first robotic gym for the rehabilitation and ... launched in Genoa, Italy . The first 30 robots ... the USA . The technology was developed and patented ... the IIT spin-off Movendo Technology thanks to a 10 million euro investment ... please click: ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
Breaking Biology News(10 mins):